Insider Transactions for SEATTLE GENETICS INC /WA (SGEN)

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This is a table of all insider transactions submitted to the SEC since mid-October of 2009. This data is up to the minute and should be current to within less than fifteen seconds of public release.

Joint filings are transactions that involve multiple parties but are reported on one form. They are grouped together by colours. Javascript is required for this feature to work.

Joint Filing? Date of Transaction Date and Time First Available Publicly Security Title Number of Shares Share Price Value of Transaction Transaction Code (Definitions) Who? Position Within Company Link to Original Filing
  2016-06-06 2016-06-08
19:32:01
Common Stock +7,618 $4.45 $33,900 M SIEGALL CLAY B
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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Director EDGAR Filing
  2016-06-06 2016-06-08
19:32:01
Common Stock +4,042 $10.20 $41,228 M SIEGALL CLAY B
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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Director EDGAR Filing
  2016-06-06 2016-06-08
19:32:01
Common Stock +10,423 $10.29 $107,253 M SIEGALL CLAY B
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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Director EDGAR Filing
  2016-05-27 2016-05-27
19:29:39
Common Stock +10,792 $10.29 $111,050 M SIEGALL CLAY B
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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Director EDGAR Filing
  2016-05-26 2016-05-27
19:29:39
Common Stock +1,130 $10.29 $11,628 M SIEGALL CLAY B
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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Director EDGAR Filing
  2016-05-25 2016-05-27
19:29:39
Common Stock +28,970 $10.29 $298,101 M SIEGALL CLAY B
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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Director EDGAR Filing
  2016-05-25 2016-05-27
19:29:39
Common Stock +7,768 $10.20 $79,234 M SIEGALL CLAY B
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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Director EDGAR Filing
  2016-05-24 2016-05-25
19:04:11
Common Stock +1,700 $10.20 $17,340 M SIEGALL CLAY B
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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Director EDGAR Filing
  2016-05-23 2016-05-25
19:04:11
Common Stock +6,700 $10.20 $68,340 M SIEGALL CLAY B
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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Director EDGAR Filing
  2016-05-20 2016-05-24
20:17:18
Common Stock +3,700 $0.00 $0 A WELCH DANIEL G
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3280 BAYSHORE BOULEVARD

BRISBANE, CA
94005
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Director EDGAR Filing
  2016-05-20 2016-05-24
20:15:28
Common Stock +3,700 $0.00 $0 A Simonian Nancy A
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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Director EDGAR Filing
  2016-05-20 2016-05-24
20:13:35
Common Stock +3,700 $0.00 $0 A Orwin John A
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C/O AFFYMAX, INC.
4001 MIRANDA AVE.
PALO ALTO, CA
94304
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Director EDGAR Filing
  2016-05-20 2016-05-24
20:09:45
Common Stock +3,700 $0.00 $0 A LIPPMAN MARC E
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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Director EDGAR Filing
  2016-05-20 2016-05-24
20:08:17
Common Stock +3,700 $0.00 $0 A GRYSKA DAVID W
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C/O CELGENE CORPORATION
86 MORRIS AVENUE
SUMMIT, NJ
07901
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Director EDGAR Filing
  2016-05-20 2016-05-24
20:05:57
Common Stock +3,700 $0.00 $0 A AKKARAJU SRINIVAS
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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Director EDGAR Filing
  2016-05-20 2016-05-24
17:50:19
Common Stock +3,700 $38.82 $143,634 A BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2016-05-20 2016-05-24
17:50:19
Common Stock +3,700 $38.82 $143,634 A BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2016-05-20 2016-05-24
17:50:19
Common Stock +3,700 $38.82 $143,634 A BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2016-05-20 2016-05-24
17:50:19
Common Stock +3,700 $38.82 $143,634 A Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2016-05-20 2016-05-24
17:50:19
Common Stock +3,700 $38.82 $143,634 A 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2016-05-20 2016-05-24
17:50:19
Common Stock +3,700 $38.82 $143,634 A Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2016-05-17 2016-05-19
15:14:28
Common Stock +7,618 $4.45 $33,900 M SIEGALL CLAY B
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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Director EDGAR Filing
  2016-04-25 2016-04-26
20:17:36
Common Stock +800 $10.20 $8,160 M SIEGALL CLAY B
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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Director EDGAR Filing
  2016-04-05 2016-04-07
16:49:31
Common Stock +7,618 $4.45 $33,900 M SIEGALL CLAY B
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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Director EDGAR Filing
  2016-03-22 2016-03-23
19:44:08
Common Stock -900 $36.14 $-32,526 S SIEGALL CLAY B
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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Director EDGAR Filing
  2016-03-22 2016-03-23
19:44:08
Common Stock -10,054 $35.69 $-358,827 S SIEGALL CLAY B
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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Director EDGAR Filing
  2016-03-22 2016-03-23
19:44:08
Common Stock +10,954 $4.45 $48,745 M SIEGALL CLAY B
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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Director EDGAR Filing
  2016-03-21 2016-03-23
19:44:08
Common Stock +4,282 $4.45 $19,055 M SIEGALL CLAY B
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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Director EDGAR Filing
  2016-03-16 2016-03-16
18:57:52
Common Stock +198,484 $31.60 $6,272,094 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2016-03-16 2016-03-16
18:57:52
Common Stock +198,484 $31.60 $6,272,094 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2016-03-16 2016-03-16
18:57:52
Common Stock +198,484 $31.60 $6,272,094 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2016-03-16 2016-03-16
18:57:52
Common Stock +198,484 $31.60 $6,272,094 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2016-03-16 2016-03-16
18:57:52
Common Stock +198,484 $31.60 $6,272,094 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2016-03-16 2016-03-16
18:57:52
Common Stock +198,484 $31.60 $6,272,094 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2016-03-16 2016-03-16
18:57:52
Common Stock +21,616 $31.60 $683,066 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2016-03-16 2016-03-16
18:57:52
Common Stock +21,616 $31.60 $683,066 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2016-03-16 2016-03-16
18:57:52
Common Stock +21,616 $31.60 $683,066 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2016-03-16 2016-03-16
18:57:52
Common Stock +21,616 $31.60 $683,066 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2016-03-16 2016-03-16
18:57:52
Common Stock +21,616 $31.60 $683,066 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2016-03-16 2016-03-16
18:57:52
Common Stock +21,616 $31.60 $683,066 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2016-03-16 2016-03-16
18:57:52
Common Stock +32,810 $31.86 $1,045,327 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2016-03-16 2016-03-16
18:57:52
Common Stock +32,810 $31.86 $1,045,327 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2016-03-16 2016-03-16
18:57:52
Common Stock +32,810 $31.86 $1,045,327 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2016-03-16 2016-03-16
18:57:52
Common Stock +32,810 $31.86 $1,045,327 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2016-03-16 2016-03-16
18:57:52
Common Stock +32,810 $31.86 $1,045,327 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2016-03-16 2016-03-16
18:57:52
Common Stock +32,810 $31.86 $1,045,327 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2016-03-16 2016-03-16
18:57:52
Common Stock +3,573 $31.86 $113,836 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2016-03-16 2016-03-16
18:57:52
Common Stock +3,573 $31.86 $113,836 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2016-03-16 2016-03-16
18:57:52
Common Stock +3,573 $31.86 $113,836 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2016-03-16 2016-03-16
18:57:52
Common Stock +3,573 $31.86 $113,836 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2016-03-16 2016-03-16
18:57:52
Common Stock +3,573 $31.86 $113,836 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2016-03-16 2016-03-16
18:57:52
Common Stock +3,573 $31.86 $113,836 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2016-03-16 2016-03-16
18:57:52
Common Stock +8,627 $31.50 $271,751 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2016-03-16 2016-03-16
18:57:52
Common Stock +8,627 $31.50 $271,751 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2016-03-16 2016-03-16
18:57:52
Common Stock +8,627 $31.50 $271,751 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2016-03-16 2016-03-16
18:57:52
Common Stock +8,627 $31.50 $271,751 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2016-03-16 2016-03-16
18:57:52
Common Stock +8,627 $31.50 $271,751 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2016-03-16 2016-03-16
18:57:52
Common Stock +8,627 $31.50 $271,751 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2016-03-16 2016-03-16
18:57:52
Common Stock +940 $31.50 $29,610 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2016-03-16 2016-03-16
18:57:52
Common Stock +940 $31.50 $29,610 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2016-03-16 2016-03-16
18:57:52
Common Stock +940 $31.50 $29,610 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2016-03-16 2016-03-16
18:57:52
Common Stock +940 $31.50 $29,610 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2016-03-16 2016-03-16
18:57:52
Common Stock +940 $31.50 $29,610 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2016-03-16 2016-03-16
18:57:52
Common Stock +940 $31.50 $29,610 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2016-03-16 2016-03-16
18:57:52
Common Stock +273,381 $31.89 $8,718,120 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2016-03-16 2016-03-16
18:57:52
Common Stock +273,381 $31.89 $8,718,120 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2016-03-16 2016-03-16
18:57:52
Common Stock +273,381 $31.89 $8,718,120 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2016-03-16 2016-03-16
18:57:52
Common Stock +273,381 $31.89 $8,718,120 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2016-03-16 2016-03-16
18:57:52
Common Stock +273,381 $31.89 $8,718,120 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2016-03-16 2016-03-16
18:57:52
Common Stock +273,381 $31.89 $8,718,120 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2016-03-16 2016-03-16
18:57:52
Common Stock +29,772 $31.89 $949,429 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2016-03-16 2016-03-16
18:57:52
Common Stock +29,772 $31.89 $949,429 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2016-03-16 2016-03-16
18:57:52
Common Stock +29,772 $31.89 $949,429 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2016-03-16 2016-03-16
18:57:52
Common Stock +29,772 $31.89 $949,429 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2016-03-16 2016-03-16
18:57:52
Common Stock +29,772 $31.89 $949,429 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2016-03-16 2016-03-16
18:57:52
Common Stock +29,772 $31.89 $949,429 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2016-03-15 2016-03-16
18:57:52
Common Stock +145,272 $31.74 $4,610,933 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2016-03-15 2016-03-16
18:57:52
Common Stock +145,272 $31.74 $4,610,933 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2016-03-15 2016-03-16
18:57:52
Common Stock +145,272 $31.74 $4,610,933 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2016-03-15 2016-03-16
18:57:52
Common Stock +145,272 $31.74 $4,610,933 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2016-03-15 2016-03-16
18:57:52
Common Stock +145,272 $31.74 $4,610,933 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2016-03-15 2016-03-16
18:57:52
Common Stock +145,272 $31.74 $4,610,933 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2016-03-15 2016-03-16
18:57:52
Common Stock +15,821 $31.74 $502,159 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2016-03-15 2016-03-16
18:57:52
Common Stock +15,821 $31.74 $502,159 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2016-03-15 2016-03-16
18:57:52
Common Stock +15,821 $31.74 $502,159 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2016-03-15 2016-03-16
18:57:52
Common Stock +15,821 $31.74 $502,159 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2016-03-15 2016-03-16
18:57:52
Common Stock +15,821 $31.74 $502,159 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2016-03-15 2016-03-16
18:57:52
Common Stock +15,821 $31.74 $502,159 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2016-03-15 2016-03-16
18:57:52
Common Stock +63,560 $31.50 $2,002,140 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2016-03-15 2016-03-16
18:57:52
Common Stock +63,560 $31.50 $2,002,140 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2016-03-15 2016-03-16
18:57:52
Common Stock +63,560 $31.50 $2,002,140 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2016-03-15 2016-03-16
18:57:52
Common Stock +63,560 $31.50 $2,002,140 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2016-03-15 2016-03-16
18:57:52
Common Stock +63,560 $31.50 $2,002,140 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2016-03-15 2016-03-16
18:57:52
Common Stock +63,560 $31.50 $2,002,140 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2016-03-15 2016-03-16
18:57:52
Common Stock +6,922 $31.50 $218,043 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2016-03-15 2016-03-16
18:57:52
Common Stock +6,922 $31.50 $218,043 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2016-03-15 2016-03-16
18:57:52
Common Stock +6,922 $31.50 $218,043 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2016-03-15 2016-03-16
18:57:52
Common Stock +6,922 $31.50 $218,043 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2016-03-15 2016-03-16
18:57:52
Common Stock +6,922 $31.50 $218,043 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2016-03-15 2016-03-16
18:57:52
Common Stock +6,922 $31.50 $218,043 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2016-03-15 2016-03-16
18:57:52
Common Stock +387,336 $32.31 $12,514,827 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2016-03-15 2016-03-16
18:57:52
Common Stock +387,336 $32.31 $12,514,827 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2016-03-15 2016-03-16
18:57:52
Common Stock +387,336 $32.31 $12,514,827 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2016-03-15 2016-03-16
18:57:52
Common Stock +387,336 $32.31 $12,514,827 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2016-03-15 2016-03-16
18:57:52
Common Stock +387,336 $32.31 $12,514,827 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2016-03-15 2016-03-16
18:57:52
Common Stock +387,336 $32.31 $12,514,827 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2016-03-15 2016-03-16
18:57:52
Common Stock +42,182 $32.31 $1,362,900 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2016-03-15 2016-03-16
18:57:52
Common Stock +42,182 $32.31 $1,362,900 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2016-03-15 2016-03-16
18:57:52
Common Stock +42,182 $32.31 $1,362,900 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2016-03-15 2016-03-16
18:57:52
Common Stock +42,182 $32.31 $1,362,900 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2016-03-15 2016-03-16
18:57:52
Common Stock +42,182 $32.31 $1,362,900 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2016-03-15 2016-03-16
18:57:52
Common Stock +42,182 $32.31 $1,362,900 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2016-03-14 2016-03-16
18:57:52
Common Stock +107,260 $33.77 $3,622,170 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2016-03-14 2016-03-16
18:57:52
Common Stock +107,260 $33.77 $3,622,170 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2016-03-14 2016-03-16
18:57:52
Common Stock +107,260 $33.77 $3,622,170 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2016-03-14 2016-03-16
18:57:52
Common Stock +107,260 $33.77 $3,622,170 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2016-03-14 2016-03-16
18:57:52
Common Stock +107,260 $33.77 $3,622,170 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2016-03-14 2016-03-16
18:57:52
Common Stock +107,260 $33.77 $3,622,170 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2016-03-14 2016-03-16
18:57:52
Common Stock +11,681 $33.77 $394,467 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2016-03-14 2016-03-16
18:57:52
Common Stock +11,681 $33.77 $394,467 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2016-03-14 2016-03-16
18:57:52
Common Stock +11,681 $33.77 $394,467 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2016-03-14 2016-03-16
18:57:52
Common Stock +11,681 $33.77 $394,467 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2016-03-14 2016-03-16
18:57:52
Common Stock +11,681 $33.77 $394,467 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2016-03-14 2016-03-16
18:57:52
Common Stock +11,681 $33.77 $394,467 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-12-15 2015-12-16
20:29:56
Common Stock +40,500 $9.23 $373,815 M HIMES VAUGHN B
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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EDGAR Filing
  2015-12-03 2015-12-04
18:01:10
Common Stock +3,720 $5.63 $20,944 M SIEGALL CLAY B
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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Director EDGAR Filing
  2015-11-17 2015-11-19
17:18:02
Common Stock -87,473 $45.40 $-3,971,274 S SIEGALL CLAY B
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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Director EDGAR Filing
  2015-11-11 2015-11-13
17:49:31
Common Stock -5,769 $45.68 $-263,528 S Cline Darren S
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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EDGAR Filing
  2015-11-10 2015-11-10
19:57:44
Common Stock +9,400 $44.00 $413,600 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-11-10 2015-11-10
19:57:44
Common Stock +9,400 $44.00 $413,600 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-11-10 2015-11-10
19:57:44
Common Stock +9,400 $44.00 $413,600 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-11-10 2015-11-10
19:57:44
Common Stock +9,400 $44.00 $413,600 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-11-10 2015-11-10
19:57:44
Common Stock +9,400 $44.00 $413,600 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-11-10 2015-11-10
19:57:44
Common Stock +9,400 $44.00 $413,600 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-11-09 2015-11-10
19:57:44
Common Stock +800 $43.00 $34,400 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-11-09 2015-11-10
19:57:44
Common Stock +800 $43.00 $34,400 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-11-09 2015-11-10
19:57:44
Common Stock +800 $43.00 $34,400 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-11-09 2015-11-10
19:57:44
Common Stock +800 $43.00 $34,400 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-11-09 2015-11-10
19:57:44
Common Stock +800 $43.00 $34,400 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-11-09 2015-11-10
19:57:44
Common Stock +800 $43.00 $34,400 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-11-09 2015-11-10
19:57:44
Common Stock +407,800 $43.71 $17,824,938 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-11-09 2015-11-10
19:57:44
Common Stock +407,800 $43.71 $17,824,938 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-11-09 2015-11-10
19:57:44
Common Stock +407,800 $43.71 $17,824,938 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-11-09 2015-11-10
19:57:44
Common Stock +407,800 $43.71 $17,824,938 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-11-09 2015-11-10
19:57:44
Common Stock +407,800 $43.71 $17,824,938 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-11-09 2015-11-10
19:57:44
Common Stock +407,800 $43.71 $17,824,938 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-11-09 2015-11-10
19:57:44
Common Stock +98,700 $44.00 $4,342,800 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-11-09 2015-11-10
19:57:44
Common Stock +98,700 $44.00 $4,342,800 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-11-09 2015-11-10
19:57:44
Common Stock +98,700 $44.00 $4,342,800 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-11-09 2015-11-10
19:57:44
Common Stock +98,700 $44.00 $4,342,800 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-11-09 2015-11-10
19:57:44
Common Stock +98,700 $44.00 $4,342,800 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-11-09 2015-11-10
19:57:44
Common Stock +98,700 $44.00 $4,342,800 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-11-06 2015-11-10
19:57:44
Common Stock +196,490 $41.31 $8,117,002 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-11-06 2015-11-10
19:57:44
Common Stock +196,490 $41.31 $8,117,002 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-11-06 2015-11-10
19:57:44
Common Stock +196,490 $41.31 $8,117,002 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-11-06 2015-11-10
19:57:44
Common Stock +196,490 $41.31 $8,117,002 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-11-06 2015-11-10
19:57:44
Common Stock +196,490 $41.31 $8,117,002 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-11-06 2015-11-10
19:57:44
Common Stock +196,490 $41.31 $8,117,002 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-11-06 2015-11-10
19:57:44
Common Stock +221,434 $42.51 $9,413,159 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-11-06 2015-11-10
19:57:44
Common Stock +221,434 $42.51 $9,413,159 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-11-06 2015-11-10
19:57:44
Common Stock +221,434 $42.51 $9,413,159 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-11-06 2015-11-10
19:57:44
Common Stock +221,434 $42.51 $9,413,159 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-11-06 2015-11-10
19:57:44
Common Stock +221,434 $42.51 $9,413,159 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-11-06 2015-11-10
19:57:44
Common Stock +221,434 $42.51 $9,413,159 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-11-06 2015-11-06
19:35:55
Common Stock -17,452 $42.50 $-741,710 S DOBMEIER ERIC
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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EDGAR Filing
  2015-11-05 2015-11-05
17:17:19
Common Stock -10,000 $43.57 $-435,700 S GRYSKA DAVID W
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C/O CELGENE CORPORATION
86 MORRIS AVENUE
SUMMIT, NJ
07901
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Director EDGAR Filing
  2015-11-04 2015-11-05
17:46:56
Common Stock +3,718 $5.63 $20,932 M SIEGALL CLAY B
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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Director EDGAR Filing
  2015-10-28 2015-10-29
20:30:01
Common Stock +18,202 $5.63 $102,477 M SIEGALL CLAY B
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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Director EDGAR Filing
  2015-10-28 2015-10-29
20:30:01
Common Stock +14,063 $4.45 $62,580 M SIEGALL CLAY B
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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Director EDGAR Filing
  2015-10-05 2015-10-07
16:47:13
Common Stock +3,718 $5.63 $20,932 M SIEGALL CLAY B
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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Director EDGAR Filing
  2015-09-15 2015-09-15
19:04:15
Common Stock +346,000 $48.44 $16,760,240 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-09-15 2015-09-15
19:04:15
Common Stock +346,000 $48.44 $16,760,240 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2015-09-15 2015-09-15
19:04:15
Common Stock +346,000 $48.44 $16,760,240 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-09-15 2015-09-15
19:04:15
Common Stock +346,000 $48.44 $16,760,240 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-15 2015-09-15
19:04:15
Common Stock +346,000 $48.44 $16,760,240 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-09-15 2015-09-15
19:04:15
Common Stock +346,000 $48.44 $16,760,240 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-09-15 2015-09-15
19:04:15
Common Stock +50,000 $47.40 $2,370,000 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-09-15 2015-09-15
19:04:15
Common Stock +50,000 $47.40 $2,370,000 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-09-15 2015-09-15
19:04:15
Common Stock +50,000 $47.40 $2,370,000 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-09-15 2015-09-15
19:04:15
Common Stock +50,000 $47.40 $2,370,000 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-09-15 2015-09-15
19:04:15
Common Stock +50,000 $47.40 $2,370,000 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-15 2015-09-15
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Common Stock +50,000 $47.40 $2,370,000 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-15 2015-09-15
19:04:15
Common Stock +160,453 $48.60 $7,798,016 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-09-15 2015-09-15
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Common Stock +160,453 $48.60 $7,798,016 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-09-15 2015-09-15
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Common Stock +160,453 $48.60 $7,798,016 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-15 2015-09-15
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Common Stock +160,453 $48.60 $7,798,016 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-15 2015-09-15
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Common Stock +160,453 $48.60 $7,798,016 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-15 2015-09-15
19:04:15
Common Stock +160,453 $48.60 $7,798,016 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-15 2015-09-15
19:04:15
Common Stock +33,320 $47.98 $1,598,694 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-09-15 2015-09-15
19:04:15
Common Stock +33,320 $47.98 $1,598,694 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-09-15 2015-09-15
19:04:15
Common Stock +33,320 $47.98 $1,598,694 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-15 2015-09-15
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Common Stock +33,320 $47.98 $1,598,694 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-15 2015-09-15
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Common Stock +33,320 $47.98 $1,598,694 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-15 2015-09-15
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Common Stock +33,320 $47.98 $1,598,694 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-15 2015-09-15
19:04:15
Common Stock +14,386 $47.54 $683,910 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-09-15 2015-09-15
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Common Stock +14,386 $47.54 $683,910 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-09-15 2015-09-15
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Common Stock +14,386 $47.54 $683,910 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-15 2015-09-15
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Common Stock +14,386 $47.54 $683,910 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-15 2015-09-15
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Common Stock +14,386 $47.54 $683,910 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-15 2015-09-15
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Common Stock +14,386 $47.54 $683,910 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-15 2015-09-15
19:04:15
Common Stock +1,600 $47.24 $75,584 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-09-15 2015-09-15
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Common Stock +1,600 $47.24 $75,584 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-09-15 2015-09-15
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Common Stock +1,600 $47.24 $75,584 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-15 2015-09-15
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Common Stock +1,600 $47.24 $75,584 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-15 2015-09-15
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Common Stock +1,600 $47.24 $75,584 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-15 2015-09-15
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Common Stock +1,600 $47.24 $75,584 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-15 2015-09-15
19:04:15
Common Stock +20,500 $46.31 $949,355 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-09-15 2015-09-15
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Common Stock +20,500 $46.31 $949,355 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-09-15 2015-09-15
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Common Stock +20,500 $46.31 $949,355 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-15 2015-09-15
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Common Stock +20,500 $46.31 $949,355 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-15 2015-09-15
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Common Stock +20,500 $46.31 $949,355 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-15 2015-09-15
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Common Stock +20,500 $46.31 $949,355 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-14 2015-09-15
19:04:15
Common Stock +1,950 $44.68 $87,126 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-09-14 2015-09-15
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Common Stock +1,950 $44.68 $87,126 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-09-14 2015-09-15
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Common Stock +1,950 $44.68 $87,126 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-14 2015-09-15
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Common Stock +1,950 $44.68 $87,126 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-14 2015-09-15
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Common Stock +1,950 $44.68 $87,126 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-14 2015-09-15
19:04:15
Common Stock +1,950 $44.68 $87,126 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-14 2015-09-15
19:04:15
Common Stock +89,843 $45.28 $4,068,091 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-09-14 2015-09-15
19:04:15
Common Stock +89,843 $45.28 $4,068,091 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-09-14 2015-09-15
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Common Stock +89,843 $45.28 $4,068,091 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-14 2015-09-15
19:04:15
Common Stock +89,843 $45.28 $4,068,091 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-14 2015-09-15
19:04:15
Common Stock +89,843 $45.28 $4,068,091 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-14 2015-09-15
19:04:15
Common Stock +89,843 $45.28 $4,068,091 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-14 2015-09-15
19:04:15
Common Stock +212,983 $46.81 $9,969,735 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-09-14 2015-09-15
19:04:15
Common Stock +212,983 $46.81 $9,969,735 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-09-14 2015-09-15
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Common Stock +212,983 $46.81 $9,969,735 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-14 2015-09-15
19:04:15
Common Stock +212,983 $46.81 $9,969,735 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-14 2015-09-15
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Common Stock +212,983 $46.81 $9,969,735 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-14 2015-09-15
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Common Stock +212,983 $46.81 $9,969,735 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-14 2015-09-15
19:04:15
Common Stock +9,818 $46.74 $458,893 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-09-14 2015-09-15
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Common Stock +9,818 $46.74 $458,893 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-09-14 2015-09-15
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Common Stock +9,818 $46.74 $458,893 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-14 2015-09-15
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Common Stock +9,818 $46.74 $458,893 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-14 2015-09-15
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Common Stock +9,818 $46.74 $458,893 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-14 2015-09-15
19:04:15
Common Stock +9,818 $46.74 $458,893 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-14 2015-09-15
19:04:15
Common Stock +2,331 $45.63 $106,364 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-09-14 2015-09-15
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Common Stock +2,331 $45.63 $106,364 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-09-14 2015-09-15
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Common Stock +2,331 $45.63 $106,364 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-14 2015-09-15
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Common Stock +2,331 $45.63 $106,364 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-14 2015-09-15
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Common Stock +2,331 $45.63 $106,364 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-14 2015-09-15
19:04:15
Common Stock +2,331 $45.63 $106,364 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-14 2015-09-15
19:04:15
Common Stock +3,513 $45.43 $159,596 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-09-14 2015-09-15
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Common Stock +3,513 $45.43 $159,596 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-09-14 2015-09-15
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Common Stock +3,513 $45.43 $159,596 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-14 2015-09-15
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Common Stock +3,513 $45.43 $159,596 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-14 2015-09-15
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Common Stock +3,513 $45.43 $159,596 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-14 2015-09-15
19:04:15
Common Stock +3,513 $45.43 $159,596 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-11 2015-09-15
19:04:15
Common Stock +13,897 $45.00 $625,365 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-09-11 2015-09-15
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Common Stock +13,897 $45.00 $625,365 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-09-11 2015-09-15
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Common Stock +13,897 $45.00 $625,365 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-11 2015-09-15
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Common Stock +13,897 $45.00 $625,365 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-11 2015-09-15
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Common Stock +13,897 $45.00 $625,365 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-11 2015-09-15
19:04:15
Common Stock +13,897 $45.00 $625,365 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-11 2015-09-15
19:04:15
Common Stock +40,649 $42.14 $1,712,949 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-09-11 2015-09-15
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Common Stock +40,649 $42.14 $1,712,949 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
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  2015-09-11 2015-09-15
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Common Stock +40,649 $42.14 $1,712,949 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-11 2015-09-15
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Common Stock +40,649 $42.14 $1,712,949 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-11 2015-09-15
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Common Stock +40,649 $42.14 $1,712,949 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-11 2015-09-15
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Common Stock +40,649 $42.14 $1,712,949 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-11 2015-09-15
19:04:15
Common Stock +8,063 $44.40 $357,997 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-09-11 2015-09-15
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Common Stock +8,063 $44.40 $357,997 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
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  2015-09-11 2015-09-15
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Common Stock +8,063 $44.40 $357,997 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-11 2015-09-15
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Common Stock +8,063 $44.40 $357,997 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-11 2015-09-15
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Common Stock +8,063 $44.40 $357,997 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-11 2015-09-15
19:04:15
Common Stock +8,063 $44.40 $357,997 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-11 2015-09-15
19:04:15
Common Stock +15,391 $40.67 $625,952 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-09-11 2015-09-15
19:04:15
Common Stock +15,391 $40.67 $625,952 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-09-11 2015-09-15
19:04:15
Common Stock +15,391 $40.67 $625,952 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-11 2015-09-15
19:04:15
Common Stock +15,391 $40.67 $625,952 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-11 2015-09-15
19:04:15
Common Stock +15,391 $40.67 $625,952 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-09-11 2015-09-15
19:04:15
Common Stock +15,391 $40.67 $625,952 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-09-11 2015-09-15
19:04:15
Common Stock +191,321 $41.06 $7,855,641 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-09-11 2015-09-15
19:04:15
Common Stock +191,321 $41.06 $7,855,641 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-09-11 2015-09-15
19:04:15
Common Stock +191,321 $41.06 $7,855,641 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-11 2015-09-15
19:04:15
Common Stock +191,321 $41.06 $7,855,641 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-11 2015-09-15
19:04:15
Common Stock +191,321 $41.06 $7,855,641 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-09-11 2015-09-15
19:04:15
Common Stock +191,321 $41.06 $7,855,641 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-09-11 2015-09-15
19:04:15
Common Stock +88,640 $42.44 $3,761,881 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2015-09-11 2015-09-15
19:04:15
Common Stock +88,640 $42.44 $3,761,881 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2015-09-11 2015-09-15
19:04:15
Common Stock +88,640 $42.44 $3,761,881 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-09-11 2015-09-15
19:04:15
Common Stock +88,640 $42.44 $3,761,881 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-09-11 2015-09-15
19:04:15
Common Stock +88,640 $42.44 $3,761,881 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-09-11 2015-09-15
19:04:15
Common Stock +88,640 $42.44 $3,761,881 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-09-11 2015-09-15
19:04:15
Common Stock +183,073 $43.28 $7,923,399 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2015-09-11 2015-09-15
19:04:15
Common Stock +183,073 $43.28 $7,923,399 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2015-09-11 2015-09-15
19:04:15
Common Stock +183,073 $43.28 $7,923,399 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-09-11 2015-09-15
19:04:15
Common Stock +183,073 $43.28 $7,923,399 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-09-11 2015-09-15
19:04:15
Common Stock +183,073 $43.28 $7,923,399 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-09-11 2015-09-15
19:04:15
Common Stock +183,073 $43.28 $7,923,399 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-09-11 2015-09-15
19:04:15
Common Stock +274,814 $44.63 $12,264,949 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2015-09-11 2015-09-15
19:04:15
Common Stock +274,814 $44.63 $12,264,949 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2015-09-11 2015-09-15
19:04:15
Common Stock +274,814 $44.63 $12,264,949 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-09-11 2015-09-15
19:04:15
Common Stock +274,814 $44.63 $12,264,949 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-09-11 2015-09-15
19:04:15
Common Stock +274,814 $44.63 $12,264,949 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-09-11 2015-09-15
19:04:15
Common Stock +274,814 $44.63 $12,264,949 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-09-11 2015-09-15
19:04:15
Common Stock +3,100 $40.55 $125,705 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2015-09-11 2015-09-15
19:04:15
Common Stock +3,100 $40.55 $125,705 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2015-09-11 2015-09-15
19:04:15
Common Stock +3,100 $40.55 $125,705 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-09-11 2015-09-15
19:04:15
Common Stock +3,100 $40.55 $125,705 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-09-11 2015-09-15
19:04:15
Common Stock +3,100 $40.55 $125,705 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-09-11 2015-09-15
19:04:15
Common Stock +3,100 $40.55 $125,705 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-09-11 2015-09-15
19:04:15
Common Stock +11,300 $41.13 $464,769 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2015-09-11 2015-09-15
19:04:15
Common Stock +11,300 $41.13 $464,769 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2015-09-11 2015-09-15
19:04:15
Common Stock +11,300 $41.13 $464,769 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-11 2015-09-15
19:04:15
Common Stock +11,300 $41.13 $464,769 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-11 2015-09-15
19:04:15
Common Stock +11,300 $41.13 $464,769 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-09-11 2015-09-15
19:04:15
Common Stock +11,300 $41.13 $464,769 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-09-11 2015-09-15
19:04:15
Common Stock +43,612 $43.60 $1,901,483 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-09-11 2015-09-15
19:04:15
Common Stock +43,612 $43.60 $1,901,483 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2015-09-11 2015-09-15
19:04:15
Common Stock +43,612 $43.60 $1,901,483 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-09-11 2015-09-15
19:04:15
Common Stock +43,612 $43.60 $1,901,483 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-09-11 2015-09-15
19:04:15
Common Stock +43,612 $43.60 $1,901,483 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-09-11 2015-09-15
19:04:15
Common Stock +43,612 $43.60 $1,901,483 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-09-11 2015-09-15
19:04:15
Common Stock +3,338,927 $41.00 $136,896,007 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2015-09-11 2015-09-15
19:04:15
Common Stock +3,338,927 $41.00 $136,896,007 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2015-09-11 2015-09-15
19:04:15
Common Stock +3,338,927 $41.00 $136,896,007 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-09-11 2015-09-15
19:04:15
Common Stock +3,338,927 $41.00 $136,896,007 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-09-11 2015-09-15
19:04:15
Common Stock +3,338,927 $41.00 $136,896,007 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-09-11 2015-09-15
19:04:15
Common Stock +3,338,927 $41.00 $136,896,007 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-09-03 2015-09-04
18:29:48
Common Stock +3,718 $5.63 $20,932 M SIEGALL CLAY B
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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Director EDGAR Filing
  2015-08-25 2015-08-25
21:28:38
Common Stock +64,000 $0.00 $0 A SIEGALL CLAY B
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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Director EDGAR Filing
  2015-08-25 2015-08-25
20:59:38
Common Stock +19,000 $0.00 $0 A DOBMEIER ERIC
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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EDGAR Filing
  2015-08-25 2015-08-25
20:48:07
Common Stock +20,000 $0.00 $0 A DRACHMAN JONATHAN G
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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EDGAR Filing
  2015-08-25 2015-08-25
20:46:55
Common Stock +12,000 $0.00 $0 A Cline Darren S
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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EDGAR Filing
  2015-08-25 2015-08-25
20:32:11
Common Stock +17,000 $0.00 $0 A SIMPSON TODD E
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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EDGAR Filing
  2015-08-25 2015-08-25
20:31:05
Common Stock +14,000 $0.00 $0 A LIU JEAN I
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2 RESULTS WAY

CUPERTINO, CA
95014
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EDGAR Filing
  2015-08-25 2015-08-25
20:30:08
Common Stock +15,000 $0.00 $0 A HIMES VAUGHN B
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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EDGAR Filing
  2015-08-24 2015-08-25
20:59:38
Common Stock +245 $15.46 $3,788 M DOBMEIER ERIC
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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EDGAR Filing
  2015-08-24 2015-08-25
20:59:38
Common Stock +4,688 $20.52 $96,198 M DOBMEIER ERIC
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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EDGAR Filing
  2015-08-20 2015-08-25
21:28:38
Common Stock -31,754 $42.02 $-1,334,303 S SIEGALL CLAY B
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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Director EDGAR Filing
  2015-08-20 2015-08-25
20:59:38
Common Stock -8,548 $42.02 $-359,187 S DOBMEIER ERIC
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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EDGAR Filing
  2015-08-20 2015-08-25
20:48:07
Common Stock -4,462 $42.02 $-187,493 S DRACHMAN JONATHAN G
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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EDGAR Filing
  2015-08-20 2015-08-25
20:46:55
Common Stock -2,231 $42.02 $-93,747 S Cline Darren S
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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EDGAR Filing
  2015-08-20 2015-08-25
20:32:11
Common Stock -5,825 $42.02 $-244,767 S SIMPSON TODD E
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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EDGAR Filing
  2015-08-20 2015-08-25
20:30:08
Common Stock -5,997 $42.02 $-251,994 S HIMES VAUGHN B
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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EDGAR Filing
  2015-08-05 2015-08-07
17:46:26
Common Stock +3,718 $5.63 $20,932 M SIEGALL CLAY B
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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Director EDGAR Filing
  2015-07-06 2015-07-08
18:07:47
Common Stock +3,718 $5.63 $20,932 M SIEGALL CLAY B
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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Director EDGAR Filing
  2015-06-03 2015-06-04
18:10:06
Common Stock +3,718 $5.63 $20,932 M SIEGALL CLAY B
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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Director EDGAR Filing
  2015-05-21 2015-05-21
19:42:59
Common Stock +198,802 $43.27 $8,602,163 P WILLIS JOHN R
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1 NORTH WACKER DRIVE
SUITE 4800
CHICAGO, IL
60606
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>=10% Owner EDGAR Filing
  2015-05-21 2015-05-21
19:42:59
Common Stock +198,802 $43.27 $8,602,163 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-05-21 2015-05-21
19:42:59
Common Stock +198,802 $43.27 $8,602,163 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2015-05-21 2015-05-21
19:42:59
Common Stock +198,802 $43.27 $8,602,163 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-21 2015-05-21
19:42:59
Common Stock +198,802 $43.27 $8,602,163 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-05-21 2015-05-21
19:42:59
Common Stock +198,802 $43.27 $8,602,163 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-21 2015-05-21
19:42:59
Common Stock +198,802 $43.27 $8,602,163 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-21 2015-05-21
19:42:59
Common Stock +57,202 $43.29 $2,476,275 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2015-05-21 2015-05-21
19:42:59
Common Stock +57,202 $43.29 $2,476,275 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2015-05-21 2015-05-21
19:42:59
Common Stock +57,202 $43.29 $2,476,275 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-21 2015-05-21
19:42:59
Common Stock +57,202 $43.29 $2,476,275 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-05-21 2015-05-21
19:42:59
Common Stock +57,202 $43.29 $2,476,275 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-05-21 2015-05-21
19:42:59
Common Stock +57,202 $43.29 $2,476,275 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-21 2015-05-21
19:42:59
Common Stock +16,300 $43.67 $711,821 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2015-05-21 2015-05-21
19:42:59
Common Stock +16,300 $43.67 $711,821 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2015-05-21 2015-05-21
19:42:59
Common Stock +16,300 $43.67 $711,821 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-21 2015-05-21
19:42:59
Common Stock +16,300 $43.67 $711,821 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-21 2015-05-21
19:42:59
Common Stock +16,300 $43.67 $711,821 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-21 2015-05-21
19:42:59
Common Stock +16,300 $43.67 $711,821 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-21 2015-05-21
19:42:59
Common Stock +90,155 $43.62 $3,932,561 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2015-05-21 2015-05-21
19:42:59
Common Stock +90,155 $43.62 $3,932,561 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2015-05-21 2015-05-21
19:42:59
Common Stock +90,155 $43.62 $3,932,561 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-21 2015-05-21
19:42:59
Common Stock +90,155 $43.62 $3,932,561 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-05-21 2015-05-21
19:42:59
Common Stock +90,155 $43.62 $3,932,561 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-05-21 2015-05-21
19:42:59
Common Stock +90,155 $43.62 $3,932,561 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-05-20 2015-05-21
19:42:59
Common Stock +150,000 $42.93 $6,439,500 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-05-20 2015-05-21
19:42:59
Common Stock +150,000 $42.93 $6,439,500 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-05-20 2015-05-21
19:42:59
Common Stock +150,000 $42.93 $6,439,500 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-05-20 2015-05-21
19:42:59
Common Stock +150,000 $42.93 $6,439,500 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-05-20 2015-05-21
19:42:59
Common Stock +150,000 $42.93 $6,439,500 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-05-20 2015-05-21
19:42:59
Common Stock +150,000 $42.93 $6,439,500 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-05-20 2015-05-21
19:42:59
Common Stock +9,200 $40.95 $376,740 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-05-20 2015-05-21
19:42:59
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-05-20 2015-05-21
19:42:59
Common Stock +9,200 $40.95 $376,740 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-05-20 2015-05-21
19:42:59
Common Stock +9,200 $40.95 $376,740 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-05-20 2015-05-21
19:42:59
Common Stock +9,200 $40.95 $376,740 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-20 2015-05-21
19:42:59
Common Stock +9,200 $40.95 $376,740 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-20 2015-05-21
19:42:59
Common Stoc +52,381 $41.54 $2,175,907 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-05-20 2015-05-21
19:42:59
Common Stoc +52,381 $41.54 $2,175,907 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2015-05-20 2015-05-21
19:42:59
Common Stoc +52,381 $41.54 $2,175,907 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-20 2015-05-21
19:42:59
Common Stoc +52,381 $41.54 $2,175,907 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-05-20 2015-05-21
19:42:59
Common Stoc +52,381 $41.54 $2,175,907 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-20 2015-05-21
19:42:59
Common Stoc +52,381 $41.54 $2,175,907 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-20 2015-05-21
19:42:59
Common Stoc +139,683 $42.68 $5,961,670 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-05-20 2015-05-21
19:42:59
Common Stoc +139,683 $42.68 $5,961,670 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-05-20 2015-05-21
19:42:59
Common Stoc +139,683 $42.68 $5,961,670 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-20 2015-05-21
19:42:59
Common Stoc +139,683 $42.68 $5,961,670 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-05-20 2015-05-21
19:42:59
Common Stoc +139,683 $42.68 $5,961,670 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-20 2015-05-21
19:42:59
Common Stoc +139,683 $42.68 $5,961,670 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-20 2015-05-21
19:42:59
Common Stoc +13,352 $42.97 $573,735 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-05-20 2015-05-21
19:42:59
Common Stoc +13,352 $42.97 $573,735 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2015-05-20 2015-05-21
19:42:59
Common Stoc +13,352 $42.97 $573,735 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-20 2015-05-21
19:42:59
Common Stoc +13,352 $42.97 $573,735 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-20 2015-05-21
19:42:59
Common Stoc +13,352 $42.97 $573,735 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-20 2015-05-21
19:42:59
Common Stoc +13,352 $42.97 $573,735 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-20 2015-05-21
19:42:59
Common Stoc +2,300 $42.15 $96,945 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-05-20 2015-05-21
19:42:59
Common Stoc +2,300 $42.15 $96,945 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2015-05-20 2015-05-21
19:42:59
Common Stoc +2,300 $42.15 $96,945 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-20 2015-05-21
19:42:59
Common Stoc +2,300 $42.15 $96,945 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-20 2015-05-21
19:42:59
Common Stoc +2,300 $42.15 $96,945 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-20 2015-05-21
19:42:59
Common Stoc +2,300 $42.15 $96,945 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-20 2015-05-21
19:42:59
Common Stock +7,382 $41.24 $304,434 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2015-05-20 2015-05-21
19:42:59
Common Stock +7,382 $41.24 $304,434 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-05-20 2015-05-21
19:42:59
Common Stock +7,382 $41.24 $304,434 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-20 2015-05-21
19:42:59
Common Stock +7,382 $41.24 $304,434 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-05-20 2015-05-21
19:42:59
Common Stock +7,382 $41.24 $304,434 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-20 2015-05-21
19:42:59
Common Stock +7,382 $41.24 $304,434 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-19 2015-05-21
19:42:59
Common Stock +4,500 $41.07 $184,815 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-05-19 2015-05-21
19:42:59
Common Stock +4,500 $41.07 $184,815 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2015-05-19 2015-05-21
19:42:59
Common Stock +4,500 $41.07 $184,815 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-05-19 2015-05-21
19:42:59
Common Stock +4,500 $41.07 $184,815 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-05-19 2015-05-21
19:42:59
Common Stock +4,500 $41.07 $184,815 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-19 2015-05-21
19:42:59
Common Stock +4,500 $41.07 $184,815 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-19 2015-05-21
19:42:59
Common Stock +89,100 $40.57 $3,614,787 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-05-19 2015-05-21
19:42:59
Common Stock +89,100 $40.57 $3,614,787 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-05-19 2015-05-21
19:42:59
Common Stock +89,100 $40.57 $3,614,787 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-19 2015-05-21
19:42:59
Common Stock +89,100 $40.57 $3,614,787 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-05-19 2015-05-21
19:42:59
Common Stock +89,100 $40.57 $3,614,787 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-05-19 2015-05-21
19:42:59
Common Stock +89,100 $40.57 $3,614,787 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-19 2015-05-21
19:42:59
Common Stock +120,529 $41.09 $4,952,537 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-05-19 2015-05-21
19:42:59
Common Stock +120,529 $41.09 $4,952,537 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-05-19 2015-05-21
19:42:59
Common Stock +120,529 $41.09 $4,952,537 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-05-19 2015-05-21
19:42:59
Common Stock +120,529 $41.09 $4,952,537 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-05-19 2015-05-21
19:42:59
Common Stock +120,529 $41.09 $4,952,537 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-05-19 2015-05-21
19:42:59
Common Stock +120,529 $41.09 $4,952,537 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-05-15 2015-05-19
19:38:34
Common Stock +3,700 $0.00 $0 A AKKARAJU SRINIVAS
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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Director EDGAR Filing
  2015-05-15 2015-05-19
19:36:40
Common Stock +3,700 $0.00 $0 A GRYSKA DAVID W
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C/O CELGENE CORPORATION
86 MORRIS AVENUE
SUMMIT, NJ
07901
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Director EDGAR Filing
  2015-05-15 2015-05-19
19:29:50
Common Stock +3,700 $0.00 $0 A Simonian Nancy A
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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Director EDGAR Filing
  2015-05-15 2015-05-19
19:27:52
Common Stock +3,700 $0.00 $0 A WELCH DANIEL G
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3280 BAYSHORE BOULEVARD

BRISBANE, CA
94005
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Director EDGAR Filing
  2015-05-15 2015-05-18
18:45:25
Common Stock +3,700 $39.94 $147,778 A BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-05-15 2015-05-18
18:45:25
Common Stock +3,700 $39.94 $147,778 A BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2015-05-15 2015-05-18
18:45:25
Common Stock +3,700 $39.94 $147,778 A BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-05-15 2015-05-18
18:45:25
Common Stock +3,700 $39.94 $147,778 A Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-05-15 2015-05-18
18:45:25
Common Stock +3,700 $39.94 $147,778 A 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-15 2015-05-18
18:45:25
Common Stock +3,700 $39.94 $147,778 A Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-11 2015-05-12
09:04:48
Common Stock +10,000 $5.11 $51,100 M BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-05-11 2015-05-12
09:04:48
Common Stock +10,000 $5.11 $51,100 M BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2015-05-11 2015-05-12
09:04:48
Common Stock +10,000 $5.11 $51,100 M BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-11 2015-05-12
09:04:48
Common Stock +10,000 $5.11 $51,100 M Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-05-11 2015-05-12
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Common Stock +10,000 $5.11 $51,100 M 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-05-11 2015-05-12
09:04:48
Common Stock +10,000 $5.11 $51,100 M Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-05-08 2015-05-08
18:50:01
Common Stock -17,074 $40.38 $-689,448 S DOBMEIER ERIC
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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EDGAR Filing
  2015-05-07 2015-05-07
21:32:18
Common Stock +1,100 $37.07 $40,777 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-05-07 2015-05-07
21:32:18
Common Stock +1,100 $37.07 $40,777 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2015-05-07 2015-05-07
21:32:18
Common Stock +1,100 $37.07 $40,777 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-07 2015-05-07
21:32:18
Common Stock +1,100 $37.07 $40,777 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-07 2015-05-07
21:32:18
Common Stock +1,100 $37.07 $40,777 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-07 2015-05-07
21:32:18
Common Stock +1,100 $37.07 $40,777 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-07 2015-05-07
21:32:18
Common Stock +46,617 $37.15 $1,731,822 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2015-05-07 2015-05-07
21:32:18
Common Stock +46,617 $37.15 $1,731,822 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2015-05-07 2015-05-07
21:32:18
Common Stock +46,617 $37.15 $1,731,822 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-07 2015-05-07
21:32:18
Common Stock +46,617 $37.15 $1,731,822 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-05-07 2015-05-07
21:32:18
Common Stock +46,617 $37.15 $1,731,822 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-05-07 2015-05-07
21:32:18
Common Stock +46,617 $37.15 $1,731,822 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-05-06 2015-05-07
21:32:18
Common Stock +8,334 $35.85 $298,774 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-05-06 2015-05-07
21:32:18
Common Stock +8,334 $35.85 $298,774 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-05-06 2015-05-07
21:32:18
Common Stock +8,334 $35.85 $298,774 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-05-06 2015-05-07
21:32:18
Common Stock +8,334 $35.85 $298,774 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-05-06 2015-05-07
21:32:18
Common Stock +8,334 $35.85 $298,774 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-05-06 2015-05-07
21:32:18
Common Stock +8,334 $35.85 $298,774 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-05-06 2015-05-07
21:32:18
Common Stock +129,118 $36.40 $4,699,895 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-05-06 2015-05-07
21:32:18
Common Stock +129,118 $36.40 $4,699,895 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-05-06 2015-05-07
21:32:18
Common Stock +129,118 $36.40 $4,699,895 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-05-06 2015-05-07
21:32:18
Common Stock +129,118 $36.40 $4,699,895 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-05-06 2015-05-07
21:32:18
Common Stock +129,118 $36.40 $4,699,895 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-05-06 2015-05-07
21:32:18
Common Stock +129,118 $36.40 $4,699,895 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-06 2015-05-07
21:32:18
Common Stoc +137,800 $36.25 $4,995,250 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-05-06 2015-05-07
21:32:18
Common Stoc +137,800 $36.25 $4,995,250 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2015-05-06 2015-05-07
21:32:18
Common Stoc +137,800 $36.25 $4,995,250 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-06 2015-05-07
21:32:18
Common Stoc +137,800 $36.25 $4,995,250 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-05-06 2015-05-07
21:32:18
Common Stoc +137,800 $36.25 $4,995,250 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-06 2015-05-07
21:32:18
Common Stoc +137,800 $36.25 $4,995,250 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-05-06 2015-05-07
21:32:18
Common Stoc +155,731 $36.67 $5,710,655 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-05-06 2015-05-07
21:32:18
Common Stoc +155,731 $36.67 $5,710,655 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-05-06 2015-05-07
21:32:18
Common Stoc +155,731 $36.67 $5,710,655 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-06 2015-05-07
21:32:18
Common Stoc +155,731 $36.67 $5,710,655 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-05-06 2015-05-07
21:32:18
Common Stoc +155,731 $36.67 $5,710,655 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-06 2015-05-07
21:32:18
Common Stoc +155,731 $36.67 $5,710,655 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-06 2015-05-07
21:32:18
Common Stoc +23,012 $35.91 $826,361 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-05-06 2015-05-07
21:32:18
Common Stoc +23,012 $35.91 $826,361 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2015-05-06 2015-05-07
21:32:18
Common Stoc +23,012 $35.91 $826,361 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-06 2015-05-07
21:32:18
Common Stoc +23,012 $35.91 $826,361 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-06 2015-05-07
21:32:18
Common Stoc +23,012 $35.91 $826,361 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-05-06 2015-05-07
21:32:18
Common Stoc +23,012 $35.91 $826,361 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-05 2015-05-07
21:32:18
Common Stoc +354,300 $34.76 $12,315,467 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2015-05-05 2015-05-07
21:32:18
Common Stoc +354,300 $34.76 $12,315,467 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2015-05-05 2015-05-07
21:32:18
Common Stoc +354,300 $34.76 $12,315,467 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-05 2015-05-07
21:32:18
Common Stoc +354,300 $34.76 $12,315,467 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-05-05 2015-05-07
21:32:18
Common Stoc +354,300 $34.76 $12,315,467 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-05 2015-05-07
21:32:18
Common Stoc +354,300 $34.76 $12,315,467 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-05 2015-05-07
21:32:18
Common Stock +59,973 $34.61 $2,075,666 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2015-05-05 2015-05-07
21:32:18
Common Stock +59,973 $34.61 $2,075,666 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2015-05-05 2015-05-07
21:32:18
Common Stock +59,973 $34.61 $2,075,666 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-05 2015-05-07
21:32:18
Common Stock +59,973 $34.61 $2,075,666 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-05 2015-05-07
21:32:18
Common Stock +59,973 $34.61 $2,075,666 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-05 2015-05-07
21:32:18
Common Stock +59,973 $34.61 $2,075,666 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-05 2015-05-07
21:32:18
Common Stock +4,330 $33.99 $147,177 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-05-05 2015-05-07
21:32:18
Common Stock +4,330 $33.99 $147,177 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2015-05-05 2015-05-07
21:32:18
Common Stock +4,330 $33.99 $147,177 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-05 2015-05-07
21:32:18
Common Stock +4,330 $33.99 $147,177 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-05 2015-05-07
21:32:18
Common Stock +4,330 $33.99 $147,177 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-05 2015-05-07
21:32:18
Common Stock +4,330 $33.99 $147,177 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-05 2015-05-07
21:32:18
Common Stock +90,397 $34.56 $3,124,120 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2015-05-05 2015-05-07
21:32:18
Common Stock +90,397 $34.56 $3,124,120 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2015-05-05 2015-05-07
21:32:18
Common Stock +90,397 $34.56 $3,124,120 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-05 2015-05-07
21:32:18
Common Stock +90,397 $34.56 $3,124,120 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-05 2015-05-07
21:32:18
Common Stock +90,397 $34.56 $3,124,120 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-05 2015-05-07
21:32:18
Common Stock +90,397 $34.56 $3,124,120 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-05 2015-05-07
21:32:18
Common Stock +21,952 $34.52 $757,783 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-05-05 2015-05-07
21:32:18
Common Stock +21,952 $34.52 $757,783 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2015-05-05 2015-05-07
21:32:18
Common Stock +21,952 $34.52 $757,783 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-05 2015-05-07
21:32:18
Common Stock +21,952 $34.52 $757,783 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-05 2015-05-07
21:32:18
Common Stock +21,952 $34.52 $757,783 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-05-05 2015-05-07
21:32:18
Common Stock +21,952 $34.52 $757,783 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-04-08 2015-04-10
18:43:17
Common Stock +5,000 $8.38 $41,900 M GRYSKA DAVID W
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C/O CELGENE CORPORATION
86 MORRIS AVENUE
SUMMIT, NJ
07901
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Director EDGAR Filing
  2015-03-12 2015-03-16
19:23:50
Common Stock +20,000 $9.23 $184,600 M HIMES VAUGHN B
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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EDGAR Filing
  2015-03-10 2015-03-11
18:55:20
Common Stock +2,880 $34.72 $99,994 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2015-03-10 2015-03-11
18:55:20
Common Stock +2,880 $34.72 $99,994 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2015-03-10 2015-03-11
18:55:20
Common Stock +2,880 $34.72 $99,994 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-03-10 2015-03-11
18:55:20
Common Stock +2,880 $34.72 $99,994 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-03-10 2015-03-11
18:55:20
Common Stock +2,880 $34.72 $99,994 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-03-10 2015-03-11
18:55:20
Common Stock +2,880 $34.72 $99,994 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-03-10 2015-03-11
18:55:20
Common Stock +6,439 $34.47 $221,952 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-03-10 2015-03-11
18:55:20
Common Stock +6,439 $34.47 $221,952 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2015-03-10 2015-03-11
18:55:20
Common Stock +6,439 $34.47 $221,952 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-03-10 2015-03-11
18:55:20
Common Stock +6,439 $34.47 $221,952 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-03-10 2015-03-11
18:55:20
Common Stock +6,439 $34.47 $221,952 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-03-10 2015-03-11
18:55:20
Common Stock +6,439 $34.47 $221,952 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-03-09 2015-03-11
18:55:20
Common Stock +158,771 $34.69 $5,507,766 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2015-03-09 2015-03-11
18:55:20
Common Stock +158,771 $34.69 $5,507,766 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2015-03-09 2015-03-11
18:55:20
Common Stock +158,771 $34.69 $5,507,766 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-03-09 2015-03-11
18:55:20
Common Stock +158,771 $34.69 $5,507,766 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-03-09 2015-03-11
18:55:20
Common Stock +158,771 $34.69 $5,507,766 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-03-09 2015-03-11
18:55:20
Common Stock +158,771 $34.69 $5,507,766 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-03-09 2015-03-11
18:55:20
Common Stock +116,946 $34.62 $4,048,670 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-03-09 2015-03-11
18:55:20
Common Stock +116,946 $34.62 $4,048,670 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2015-03-09 2015-03-11
18:55:20
Common Stock +116,946 $34.62 $4,048,670 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-03-09 2015-03-11
18:55:20
Common Stock +116,946 $34.62 $4,048,670 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-03-09 2015-03-11
18:55:20
Common Stock +116,946 $34.62 $4,048,670 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-03-09 2015-03-11
18:55:20
Common Stock +116,946 $34.62 $4,048,670 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2015-02-25 2015-02-26
19:12:13
Common Stock +1,000 $35.59 $35,590 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-02-25 2015-02-26
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Common Stock +1,000 $35.59 $35,590 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-02-25 2015-02-26
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Common Stock +1,000 $35.59 $35,590 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-02-25 2015-02-26
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Common Stock +1,000 $35.59 $35,590 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-02-25 2015-02-26
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Common Stock +1,000 $35.59 $35,590 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-02-25 2015-02-26
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Common Stock +1,000 $35.59 $35,590 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-02-25 2015-02-26
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Common Stock +62,650 $34.46 $2,158,919 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-02-25 2015-02-26
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-02-25 2015-02-26
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-02-25 2015-02-26
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Common Stock +62,650 $34.46 $2,158,919 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-02-25 2015-02-26
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Common Stock +62,650 $34.46 $2,158,919 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-02-25 2015-02-26
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Common Stock +62,650 $34.46 $2,158,919 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-02-24 2015-02-26
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Common Stock +163,054 $33.80 $5,511,225 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-02-24 2015-02-26
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-02-24 2015-02-26
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Common Stock +163,054 $33.80 $5,511,225 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-02-24 2015-02-26
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
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  2015-02-24 2015-02-26
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Common Stock +163,054 $33.80 $5,511,225 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-02-24 2015-02-26
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Common Stock +163,054 $33.80 $5,511,225 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-02-24 2015-02-26
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Common Stock +4,995 $33.60 $167,832 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-02-24 2015-02-26
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
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  2015-02-24 2015-02-26
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Common Stock +4,995 $33.60 $167,832 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-02-24 2015-02-26
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Common Stock +4,995 $33.60 $167,832 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
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  2015-02-24 2015-02-26
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-02-24 2015-02-26
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Common Stock +4,995 $33.60 $167,832 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2015-02-24 2015-02-26
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Common Stock +49,416 $33.65 $1,662,848 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2015-02-24 2015-02-26
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
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  2015-02-24 2015-02-26
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
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  2015-02-24 2015-02-26
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
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  2015-02-24 2015-02-26
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
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  2015-02-24 2015-02-26
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
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  2015-01-06 2015-01-08
17:47:52
Common Stock +16,804 $5.92 $99,480 M SIEGALL CLAY B
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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  2014-12-10 2014-12-10
20:04:01
Common Stock +100,000 $34.95 $3,495,000 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
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  2014-12-10 2014-12-10
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
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  2014-12-10 2014-12-10
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
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  2014-12-10 2014-12-10
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
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  2014-12-10 2014-12-10
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
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  2014-12-10 2014-12-10
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
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  2014-12-10 2014-12-10
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Common Stock +100,000 $34.95 $3,495,000 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
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  2014-12-10 2014-12-10
20:04:01
Common Stock +354,000 $34.27 $12,131,580 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
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  2014-12-10 2014-12-10
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
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  2014-12-10 2014-12-10
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
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  2014-12-10 2014-12-10
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
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  2014-12-10 2014-12-10
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
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  2014-12-10 2014-12-10
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
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  2014-12-10 2014-12-10
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Common Stock +354,000 $34.27 $12,131,580 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
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  2014-12-10 2014-12-10
20:04:01
Common Stock +14,772 $34.53 $510,077 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
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  2014-12-10 2014-12-10
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
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  2014-12-10 2014-12-10
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
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  2014-12-10 2014-12-10
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
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  2014-12-10 2014-12-10
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
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  2014-12-10 2014-12-10
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
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  2014-12-10 2014-12-10
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
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  2014-12-10 2014-12-10
20:04:01
Common Stock +185,378 $34.33 $6,364,027 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
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  2014-12-10 2014-12-10
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
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  2014-12-10 2014-12-10
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
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  2014-12-10 2014-12-10
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
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  2014-12-10 2014-12-10
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
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  2014-12-10 2014-12-10
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Common Stock +185,378 $34.33 $6,364,027 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
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  2014-12-10 2014-12-10
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Common Stock +185,378 $34.33 $6,364,027 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
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  2014-12-09 2014-12-10
20:04:01
Common Stock +30,507 $0.00 $0 J BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
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  2014-12-09 2014-12-10
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
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  2014-12-09 2014-12-10
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Common Stock +30,507 $0.00 $0 J BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
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  2014-12-09 2014-12-10
20:04:01
Common Stock +30,507 $0.00 $0 J Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
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  2014-12-09 2014-12-10
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
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  2014-12-09 2014-12-10
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
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  2014-12-09 2014-12-10
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Common Stock +30,507 $0.00 $0 J Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
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  2014-12-09 2014-12-10
20:04:01
Common Stock -399,208 $0.00 $0 J BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
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  2014-12-09 2014-12-10
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Common Stock -399,208 $0.00 $0 J BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
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  2014-12-09 2014-12-10
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Common Stock -399,208 $0.00 $0 J BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
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  2014-12-09 2014-12-10
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Common Stock -399,208 $0.00 $0 J Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
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  2014-12-09 2014-12-10
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
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  2014-12-09 2014-12-10
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Common Stock -399,208 $0.00 $0 J 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-12-09 2014-12-10
20:04:01
Common Stock -399,208 $0.00 $0 J Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
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  2014-12-09 2014-12-10
20:04:01
Common Stock +5,500 $33.90 $186,450 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
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  2014-12-09 2014-12-10
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
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  2014-12-09 2014-12-10
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
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  2014-12-09 2014-12-10
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
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  2014-12-09 2014-12-10
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
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  2014-12-09 2014-12-10
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-12-09 2014-12-10
20:04:01
Common Stock +5,500 $33.90 $186,450 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
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  2014-12-09 2014-12-10
20:04:01
Common Stock +80,430 $34.64 $2,786,095 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
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  2014-12-09 2014-12-10
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
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  2014-12-09 2014-12-10
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
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  2014-12-09 2014-12-10
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
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  2014-12-09 2014-12-10
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
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  2014-12-09 2014-12-10
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
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  2014-12-09 2014-12-10
20:04:01
Common Stock +80,430 $34.64 $2,786,095 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
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  2014-12-09 2014-12-10
20:04:01
Common Stock +42,500 $33.28 $1,414,400 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
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  2014-12-09 2014-12-10
20:04:01
Common Stock +42,500 $33.28 $1,414,400 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
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  2014-12-09 2014-12-10
20:04:01
Common Stock +42,500 $33.28 $1,414,400 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
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  2014-12-09 2014-12-10
20:04:01
Common Stock +42,500 $33.28 $1,414,400 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-12-09 2014-12-10
20:04:01
Common Stock +42,500 $33.28 $1,414,400 P 14159, L.P.
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-12-09 2014-12-10
20:04:01
Common Stock +42,500 $33.28 $1,414,400 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-12-09 2014-12-10
20:04:01
Common Stock +42,500 $33.28 $1,414,400 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-12-08 2014-12-10
20:04:01
Common Stock +185,528 $33.31 $6,179,938 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-12-08 2014-12-10
20:04:01
Common Stock +185,528 $33.31 $6,179,938 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-12-08 2014-12-10
20:04:01
Common Stock +185,528 $33.31 $6,179,938 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-12-08 2014-12-10
20:04:01
Common Stock +185,528 $33.31 $6,179,938 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-12-08 2014-12-10
20:04:01
Common Stock +185,528 $33.31 $6,179,938 P 14159, L.P.
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-12-08 2014-12-10
20:04:01
Common Stock +185,528 $33.31 $6,179,938 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-12-08 2014-12-10
20:04:01
Common Stock +185,528 $33.31 $6,179,938 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-12-08 2014-12-10
20:04:01
Common Stock +216,284 $32.56 $7,042,207 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-12-08 2014-12-10
20:04:01
Common Stock +216,284 $32.56 $7,042,207 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-12-08 2014-12-10
20:04:01
Common Stock +216,284 $32.56 $7,042,207 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-12-08 2014-12-10
20:04:01
Common Stock +216,284 $32.56 $7,042,207 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-12-08 2014-12-10
20:04:01
Common Stock +216,284 $32.56 $7,042,207 P 14159, L.P.
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-12-08 2014-12-10
20:04:01
Common Stock +216,284 $32.56 $7,042,207 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-12-08 2014-12-10
20:04:01
Common Stock +216,284 $32.56 $7,042,207 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-12-08 2014-12-10
20:04:01
Common Stock +38,614 $33.00 $1,274,262 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-12-08 2014-12-10
20:04:01
Common Stock +38,614 $33.00 $1,274,262 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-12-08 2014-12-10
20:04:01
Common Stock +38,614 $33.00 $1,274,262 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-12-08 2014-12-10
20:04:01
Common Stock +38,614 $33.00 $1,274,262 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-12-08 2014-12-10
20:04:01
Common Stock +38,614 $33.00 $1,274,262 P 14159, L.P.
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-12-08 2014-12-10
20:04:01
Common Stock +38,614 $33.00 $1,274,262 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-12-08 2014-12-10
20:04:01
Common Stock +38,614 $33.00 $1,274,262 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-12-08 2014-12-10
20:04:01
Common Stock +24,890 $33.06 $822,863 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-12-08 2014-12-10
20:04:01
Common Stock +24,890 $33.06 $822,863 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-12-08 2014-12-10
20:04:01
Common Stock +24,890 $33.06 $822,863 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-12-08 2014-12-10
20:04:01
Common Stock +24,890 $33.06 $822,863 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-12-08 2014-12-10
20:04:01
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-12-08 2014-12-10
20:04:01
Common Stock +24,890 $33.06 $822,863 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-12-08 2014-12-10
20:04:01
Common Stock +24,890 $33.06 $822,863 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-12-01 2014-12-03
20:13:41
Common Stock +22,400 $0.00 $0 A LIU JEAN I
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2 RESULTS WAY

CUPERTINO, CA
95014
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EDGAR Filing
  2014-11-10 2014-11-10
18:52:59
Common Stock +98,076 $36.57 $3,586,639 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-11-10 2014-11-10
18:52:59
Common Stock +98,076 $36.57 $3,586,639 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-11-10 2014-11-10
18:52:59
Common Stock +98,076 $36.57 $3,586,639 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-10 2014-11-10
18:52:59
Common Stock +98,076 $36.57 $3,586,639 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-10 2014-11-10
18:52:59
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-10 2014-11-10
18:52:59
Common Stock +98,076 $36.57 $3,586,639 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-10 2014-11-10
18:52:59
Common Stock +98,076 $36.57 $3,586,639 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-10 2014-11-10
18:52:59
Common Stock +10,639 $36.75 $390,983 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-11-10 2014-11-10
18:52:59
Common Stock +10,639 $36.75 $390,983 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-11-10 2014-11-10
18:52:59
Common Stock +10,639 $36.75 $390,983 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-10 2014-11-10
18:52:59
Common Stock +10,639 $36.75 $390,983 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-10 2014-11-10
18:52:59
Common Stock +10,639 $36.75 $390,983 P 14159, L.P.
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-10 2014-11-10
18:52:59
Common Stock +10,639 $36.75 $390,983 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-10 2014-11-10
18:52:59
Common Stock +10,639 $36.75 $390,983 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-10 2014-11-10
18:52:59
Common Stock +69,397 $35.88 $2,489,964 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-11-10 2014-11-10
18:52:59
Common Stock +69,397 $35.88 $2,489,964 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-11-10 2014-11-10
18:52:59
Common Stock +69,397 $35.88 $2,489,964 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-10 2014-11-10
18:52:59
Common Stock +69,397 $35.88 $2,489,964 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-10 2014-11-10
18:52:59
Common Stock +69,397 $35.88 $2,489,964 P 14159, L.P.
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-10 2014-11-10
18:52:59
Common Stock +69,397 $35.88 $2,489,964 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-10 2014-11-10
18:52:59
Common Stock +69,397 $35.88 $2,489,964 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-10 2014-11-10
18:52:59
Common Stock +63,137 $36.74 $2,319,653 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-11-10 2014-11-10
18:52:59
Common Stock +63,137 $36.74 $2,319,653 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-11-10 2014-11-10
18:52:59
Common Stock +63,137 $36.74 $2,319,653 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-10 2014-11-10
18:52:59
Common Stock +63,137 $36.74 $2,319,653 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-10 2014-11-10
18:52:59
Common Stock +63,137 $36.74 $2,319,653 P 14159, L.P.
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-10 2014-11-10
18:52:59
Common Stock +63,137 $36.74 $2,319,653 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-10 2014-11-10
18:52:59
Common Stock +63,137 $36.74 $2,319,653 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-07 2014-11-10
18:52:59
Common Stock +25,505 $35.91 $915,885 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-11-07 2014-11-10
18:52:59
Common Stock +25,505 $35.91 $915,885 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-11-07 2014-11-10
18:52:59
Common Stock +25,505 $35.91 $915,885 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-07 2014-11-10
18:52:59
Common Stock +25,505 $35.91 $915,885 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-07 2014-11-10
18:52:59
Common Stock +25,505 $35.91 $915,885 P 14159, L.P.
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-07 2014-11-10
18:52:59
Common Stock +25,505 $35.91 $915,885 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-07 2014-11-10
18:52:59
Common Stock +25,505 $35.91 $915,885 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-07 2014-11-10
18:52:59
Common Stock +22,839 $35.55 $811,926 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-11-07 2014-11-10
18:52:59
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-11-07 2014-11-10
18:52:59
Common Stock +22,839 $35.55 $811,926 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-07 2014-11-10
18:52:59
Common Stock +22,839 $35.55 $811,926 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-07 2014-11-10
18:52:59
Common Stock +22,839 $35.55 $811,926 P 14159, L.P.
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-07 2014-11-10
18:52:59
Common Stock +22,839 $35.55 $811,926 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-07 2014-11-10
18:52:59
Common Stock +22,839 $35.55 $811,926 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-07 2014-11-10
18:52:59
Common Stock +13,116 $35.56 $466,405 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-11-07 2014-11-10
18:52:59
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-11-07 2014-11-10
18:52:59
Common Stock +13,116 $35.56 $466,405 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-07 2014-11-10
18:52:59
Common Stock +13,116 $35.56 $466,405 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-07 2014-11-10
18:52:59
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-07 2014-11-10
18:52:59
Common Stock +13,116 $35.56 $466,405 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-07 2014-11-10
18:52:59
Common Stock +13,116 $35.56 $466,405 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-07 2014-11-10
18:52:59
Common Stock +17,098 $34.91 $596,891 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-11-07 2014-11-10
18:52:59
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-11-07 2014-11-10
18:52:59
Common Stock +17,098 $34.91 $596,891 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-07 2014-11-10
18:52:59
Common Stock +17,098 $34.91 $596,891 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-07 2014-11-10
18:52:59
Common Stock +17,098 $34.91 $596,891 P 14159, L.P.
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-07 2014-11-10
18:52:59
Common Stock +17,098 $34.91 $596,891 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-07 2014-11-10
18:52:59
Common Stock +17,098 $34.91 $596,891 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-07 2014-11-10
18:52:59
Common Stock +104,140 $35.98 $3,746,957 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-11-07 2014-11-10
18:52:59
Common Stock +104,140 $35.98 $3,746,957 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-11-07 2014-11-10
18:52:59
Common Stock +104,140 $35.98 $3,746,957 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-07 2014-11-10
18:52:59
Common Stock +104,140 $35.98 $3,746,957 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-07 2014-11-10
18:52:59
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-07 2014-11-10
18:52:59
Common Stock +104,140 $35.98 $3,746,957 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-07 2014-11-10
18:52:59
Common Stock +104,140 $35.98 $3,746,957 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-07 2014-11-10
18:52:59
Common Stock +29,006 $35.28 $1,023,332 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-11-07 2014-11-10
18:52:59
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-11-07 2014-11-10
18:52:59
Common Stock +29,006 $35.28 $1,023,332 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-07 2014-11-10
18:52:59
Common Stock +29,006 $35.28 $1,023,332 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-07 2014-11-10
18:52:59
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-07 2014-11-10
18:52:59
Common Stock +29,006 $35.28 $1,023,332 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-07 2014-11-10
18:52:59
Common Stock +29,006 $35.28 $1,023,332 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-06 2014-11-10
18:52:59
Common Stock +13,500 $34.26 $462,510 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-11-06 2014-11-10
18:52:59
Common Stock +13,500 $34.26 $462,510 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-11-06 2014-11-10
18:52:59
Common Stock +13,500 $34.26 $462,510 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-06 2014-11-10
18:52:59
Common Stock +13,500 $34.26 $462,510 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-06 2014-11-10
18:52:59
Common Stock +13,500 $34.26 $462,510 P 14159, L.P.
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-06 2014-11-10
18:52:59
Common Stock +13,500 $34.26 $462,510 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-06 2014-11-10
18:52:59
Common Stock +13,500 $34.26 $462,510 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-06 2014-11-10
18:52:59
Common Stock +25,769 $34.58 $891,092 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-11-06 2014-11-10
18:52:59
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-11-06 2014-11-10
18:52:59
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-06 2014-11-10
18:52:59
Common Stock +25,769 $34.58 $891,092 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-06 2014-11-10
18:52:59
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-06 2014-11-10
18:52:59
Common Stock +25,769 $34.58 $891,092 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-06 2014-11-10
18:52:59
Common Stock +25,769 $34.58 $891,092 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-06 2014-11-10
18:52:59
Common Stock +866,669 $33.79 $29,284,746 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-11-06 2014-11-10
18:52:59
Common Stock +866,669 $33.79 $29,284,746 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-11-06 2014-11-10
18:52:59
Common Stock +866,669 $33.79 $29,284,746 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-06 2014-11-10
18:52:59
Common Stock +866,669 $33.79 $29,284,746 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-06 2014-11-10
18:52:59
Common Stock +866,669 $33.79 $29,284,746 P 14159, L.P.
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-06 2014-11-10
18:52:59
Common Stock +866,669 $33.79 $29,284,746 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-06 2014-11-10
18:52:59
Common Stock +866,669 $33.79 $29,284,746 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-06 2014-11-10
18:52:59
Common Stock +4,394 $33.71 $148,122 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-11-06 2014-11-10
18:52:59
Common Stock +4,394 $33.71 $148,122 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-11-06 2014-11-10
18:52:59
Common Stock +4,394 $33.71 $148,122 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-06 2014-11-10
18:52:59
Common Stock +4,394 $33.71 $148,122 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-06 2014-11-10
18:52:59
Common Stock +4,394 $33.71 $148,122 P 14159, L.P.
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-06 2014-11-10
18:52:59
Common Stock +4,394 $33.71 $148,122 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-06 2014-11-10
18:52:59
Common Stock +4,394 $33.71 $148,122 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-06 2014-11-10
18:52:59
Common Stock +38,166 $34.83 $1,329,322 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-11-06 2014-11-10
18:52:59
Common Stock +38,166 $34.83 $1,329,322 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-11-06 2014-11-10
18:52:59
Common Stock +38,166 $34.83 $1,329,322 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-06 2014-11-10
18:52:59
Common Stock +38,166 $34.83 $1,329,322 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-06 2014-11-10
18:52:59
Common Stock +38,166 $34.83 $1,329,322 P 14159, L.P.
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-06 2014-11-10
18:52:59
Common Stock +38,166 $34.83 $1,329,322 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-06 2014-11-10
18:52:59
Common Stock +38,166 $34.83 $1,329,322 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-06 2014-11-10
18:52:59
Common Stock +252,474 $34.41 $8,687,630 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-11-06 2014-11-10
18:52:59
Common Stock +252,474 $34.41 $8,687,630 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-11-06 2014-11-10
18:52:59
Common Stock +252,474 $34.41 $8,687,630 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-06 2014-11-10
18:52:59
Common Stock +252,474 $34.41 $8,687,630 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-06 2014-11-10
18:52:59
Common Stock +252,474 $34.41 $8,687,630 P 14159, L.P.
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-06 2014-11-10
18:52:59
Common Stock +252,474 $34.41 $8,687,630 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-11-06 2014-11-10
18:52:59
Common Stock +252,474 $34.41 $8,687,630 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-09-04 2014-09-05
19:19:08
Common Stock +5,600 $5.92 $33,152 M SIEGALL CLAY B
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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  2014-08-27 2014-08-28
16:27:42
Common Stock +8,333 $12.00 $99,996 M DOBMEIER ERIC
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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EDGAR Filing
  2014-08-12 2014-08-13
19:28:38
Common Stock +8,500 $5.92 $50,320 M SIEGALL CLAY B
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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  2014-08-11 2014-08-13
19:28:38
Common Stock +2,700 $5.92 $15,984 M SIEGALL CLAY B
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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  2014-06-10 2014-06-12
20:33:19
Common Stock +11,200 $5.92 $66,304 M SIEGALL CLAY B
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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  2014-06-09 2014-06-09
17:26:24
Common Stock +5,534 $38.96 $215,605 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-06-09 2014-06-09
17:26:24
Common Stock +5,534 $38.96 $215,605 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-06-09 2014-06-09
17:26:24
Common Stock +5,534 $38.96 $215,605 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-09 2014-06-09
17:26:24
Common Stock +5,534 $38.96 $215,605 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-09 2014-06-09
17:26:24
Common Stock +5,534 $38.96 $215,605 P 14159, L.P.
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-09 2014-06-09
17:26:24
Common Stock +5,534 $38.96 $215,605 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-09 2014-06-09
17:26:24
Common Stock +5,534 $38.96 $215,605 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-09 2014-06-09
17:26:24
Common Stock +223,466 $38.96 $8,706,235 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-06-09 2014-06-09
17:26:24
Common Stock +223,466 $38.96 $8,706,235 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-06-09 2014-06-09
17:26:24
Common Stock +223,466 $38.96 $8,706,235 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-09 2014-06-09
17:26:24
Common Stock +223,466 $38.96 $8,706,235 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-09 2014-06-09
17:26:24
Common Stock +223,466 $38.96 $8,706,235 P 14159, L.P.
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-09 2014-06-09
17:26:24
Common Stock +223,466 $38.96 $8,706,235 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-09 2014-06-09
17:26:24
Common Stock +223,466 $38.96 $8,706,235 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-09 2014-06-09
17:26:24
Common Stock +534 $38.56 $20,591 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-06-09 2014-06-09
17:26:24
Common Stock +534 $38.56 $20,591 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-06-09 2014-06-09
17:26:24
Common Stock +534 $38.56 $20,591 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-09 2014-06-09
17:26:24
Common Stock +534 $38.56 $20,591 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-09 2014-06-09
17:26:24
Common Stock +534 $38.56 $20,591 P 14159, L.P.
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-09 2014-06-09
17:26:24
Common Stock +534 $38.56 $20,591 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-09 2014-06-09
17:26:24
Common Stock +534 $38.56 $20,591 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-09 2014-06-09
17:26:24
Common Stock +21,559 $38.56 $831,315 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-06-09 2014-06-09
17:26:24
Common Stock +21,559 $38.56 $831,315 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-06-09 2014-06-09
17:26:24
Common Stock +21,559 $38.56 $831,315 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-09 2014-06-09
17:26:24
Common Stock +21,559 $38.56 $831,315 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-09 2014-06-09
17:26:24
Common Stock +21,559 $38.56 $831,315 P 14159, L.P.
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-09 2014-06-09
17:26:24
Common Stock +21,559 $38.56 $831,315 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-09 2014-06-09
17:26:24
Common Stock +21,559 $38.56 $831,315 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-06 2014-06-09
17:26:24
Common Stock +477 $37.52 $17,897 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-06-06 2014-06-09
17:26:24
Common Stock +477 $37.52 $17,897 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-06-06 2014-06-09
17:26:24
Common Stock +477 $37.52 $17,897 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-06 2014-06-09
17:26:24
Common Stock +477 $37.52 $17,897 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-06 2014-06-09
17:26:24
Common Stock +477 $37.52 $17,897 P 14159, L.P.
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-06 2014-06-09
17:26:24
Common Stock +477 $37.52 $17,897 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-06 2014-06-09
17:26:24
Common Stock +477 $37.52 $17,897 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-06 2014-06-09
17:26:24
Common Stock +19,223 $37.52 $721,247 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-06-06 2014-06-09
17:26:24
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-06-06 2014-06-09
17:26:24
Common Stock +19,223 $37.52 $721,247 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-06 2014-06-09
17:26:24
Common Stock +19,223 $37.52 $721,247 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-06 2014-06-09
17:26:24
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-06 2014-06-09
17:26:24
Common Stock +19,223 $37.52 $721,247 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-06 2014-06-09
17:26:24
Common Stock +19,223 $37.52 $721,247 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-06 2014-06-09
17:26:24
Common Stock +3,757 $37.40 $140,512 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-06-06 2014-06-09
17:26:24
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-06-06 2014-06-09
17:26:24
Common Stock +3,757 $37.40 $140,512 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-06 2014-06-09
17:26:24
Common Stock +3,757 $37.40 $140,512 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-06 2014-06-09
17:26:24
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-06 2014-06-09
17:26:24
Common Stock +3,757 $37.40 $140,512 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-06 2014-06-09
17:26:24
Common Stock +3,757 $37.40 $140,512 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-06 2014-06-09
17:26:24
Common Stock +151,530 $37.40 $5,667,222 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-06-06 2014-06-09
17:26:24
Common Stock +151,530 $37.40 $5,667,222 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-06-06 2014-06-09
17:26:24
Common Stock +151,530 $37.40 $5,667,222 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-06 2014-06-09
17:26:24
Common Stock +151,530 $37.40 $5,667,222 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-06 2014-06-09
17:26:24
Common Stock +151,530 $37.40 $5,667,222 P 14159, L.P.
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-06 2014-06-09
17:26:24
Common Stock +151,530 $37.40 $5,667,222 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-06 2014-06-09
17:26:24
Common Stock +151,530 $37.40 $5,667,222 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-05 2014-06-09
17:26:24
Common Stock +2,411 $37.67 $90,822 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-06-05 2014-06-09
17:26:24
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-06-05 2014-06-09
17:26:24
Common Stock +2,411 $37.67 $90,822 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-05 2014-06-09
17:26:24
Common Stock +2,411 $37.67 $90,822 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-05 2014-06-09
17:26:24
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-05 2014-06-09
17:26:24
Common Stock +2,411 $37.67 $90,822 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-05 2014-06-09
17:26:24
Common Stock +2,411 $37.67 $90,822 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-05 2014-06-09
17:26:24
Common Stock +97,254 $37.67 $3,663,558 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-06-05 2014-06-09
17:26:24
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-06-05 2014-06-09
17:26:24
Common Stock +97,254 $37.67 $3,663,558 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-05 2014-06-09
17:26:24
Common Stock +97,254 $37.67 $3,663,558 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-05 2014-06-09
17:26:24
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-05 2014-06-09
17:26:24
Common Stock +97,254 $37.67 $3,663,558 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-05 2014-06-09
17:26:24
Common Stock +97,254 $37.67 $3,663,558 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-05 2014-06-09
17:26:24
Common Stock +496 $37.63 $18,664 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-06-05 2014-06-09
17:26:24
Common Stock +496 $37.63 $18,664 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-06-05 2014-06-09
17:26:24
Common Stock +496 $37.63 $18,664 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-05 2014-06-09
17:26:24
Common Stock +496 $37.63 $18,664 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-05 2014-06-09
17:26:24
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-05 2014-06-09
17:26:24
Common Stock +496 $37.63 $18,664 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-05 2014-06-09
17:26:24
Common Stock +496 $37.63 $18,664 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-05 2014-06-09
17:26:24
Common Stock +20,011 $37.63 $753,014 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-06-05 2014-06-09
17:26:24
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-06-05 2014-06-09
17:26:24
Common Stock +20,011 $37.63 $753,014 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-05 2014-06-09
17:26:24
Common Stock +20,011 $37.63 $753,014 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-05 2014-06-09
17:26:24
Common Stock +20,011 $37.63 $753,014 P 14159, L.P.
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-05 2014-06-09
17:26:24
Common Stock +20,011 $37.63 $753,014 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-05 2014-06-09
17:26:24
Common Stock +20,011 $37.63 $753,014 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-04 2014-06-04
19:27:08
Common Stock +1,534 $36.04 $55,285 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-06-04 2014-06-04
19:27:08
Common Stock +1,534 $36.04 $55,285 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-06-04 2014-06-04
19:27:08
Common Stock +1,534 $36.04 $55,285 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-04 2014-06-04
19:27:08
Common Stock +1,534 $36.04 $55,285 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-04 2014-06-04
19:27:08
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-04 2014-06-04
19:27:08
Common Stock +1,534 $36.04 $55,285 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-04 2014-06-04
19:27:08
Common Stock +1,534 $36.04 $55,285 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-04 2014-06-04
19:27:08
Common Stock +61,878 $36.04 $2,230,083 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-06-04 2014-06-04
19:27:08
Common Stock +61,878 $36.04 $2,230,083 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-06-04 2014-06-04
19:27:08
Common Stock +61,878 $36.04 $2,230,083 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-04 2014-06-04
19:27:08
Common Stock +61,878 $36.04 $2,230,083 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-04 2014-06-04
19:27:08
Common Stock +61,878 $36.04 $2,230,083 P 14159, L.P.
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-04 2014-06-04
19:27:08
Common Stock +61,878 $36.04 $2,230,083 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-04 2014-06-04
19:27:08
Common Stock +61,878 $36.04 $2,230,083 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-04 2014-06-04
19:27:08
Common Stock +572 $36.39 $20,815 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-06-04 2014-06-04
19:27:08
Common Stock +572 $36.39 $20,815 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-06-04 2014-06-04
19:27:08
Common Stock +572 $36.39 $20,815 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-04 2014-06-04
19:27:08
Common Stock +572 $36.39 $20,815 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-04 2014-06-04
19:27:08
Common Stock +572 $36.39 $20,815 P 14159, L.P.
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-04 2014-06-04
19:27:08
Common Stock +572 $36.39 $20,815 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-04 2014-06-04
19:27:08
Common Stock +572 $36.39 $20,815 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-04 2014-06-04
19:27:08
Common Stock +23,058 $36.39 $839,081 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-06-04 2014-06-04
19:27:08
Common Stock +23,058 $36.39 $839,081 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-06-04 2014-06-04
19:27:08
Common Stock +23,058 $36.39 $839,081 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-04 2014-06-04
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Common Stock +23,058 $36.39 $839,081 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-04 2014-06-04
19:27:08
Common Stock +23,058 $36.39 $839,081 P 14159, L.P.
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-04 2014-06-04
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Common Stock +23,058 $36.39 $839,081 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-04 2014-06-04
19:27:08
Common Stock +23,058 $36.39 $839,081 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-03 2014-06-04
19:27:08
Common Stock +19 $35.27 $670 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-06-03 2014-06-04
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-06-03 2014-06-04
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Common Stock +19 $35.27 $670 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-03 2014-06-04
19:27:08
Common Stock +19 $35.27 $670 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-03 2014-06-04
19:27:08
Common Stock +19 $35.27 $670 P 14159, L.P.
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-03 2014-06-04
19:27:08
Common Stock +19 $35.27 $670 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-03 2014-06-04
19:27:08
Common Stock +19 $35.27 $670 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-03 2014-06-04
19:27:08
Common Stock +781 $35.27 $27,546 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-06-03 2014-06-04
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-06-03 2014-06-04
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-03 2014-06-04
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NEW YORK, NY
US 10065
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  2014-06-03 2014-06-04
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NEW YORK, NY
US 10065
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  2014-06-03 2014-06-04
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-03 2014-06-04
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-03 2014-06-04
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-06-03 2014-06-04
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NEW YORK, NY
US 10021
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  2014-06-03 2014-06-04
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-03 2014-06-04
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-03 2014-06-04
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NEW YORK, NY
US 10065
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  2014-06-03 2014-06-04
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-03 2014-06-04
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-03 2014-06-04
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Common Stock +86,201 $34.38 $2,963,590 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-06-03 2014-06-04
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-06-03 2014-06-04
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-03 2014-06-04
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-03 2014-06-04
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-03 2014-06-04
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-03 2014-06-04
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-03 2014-06-04
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-06-03 2014-06-04
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-06-03 2014-06-04
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-03 2014-06-04
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-03 2014-06-04
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-03 2014-06-04
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-03 2014-06-04
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-03 2014-06-04
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-06-03 2014-06-04
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-06-03 2014-06-04
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-03 2014-06-04
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-03 2014-06-04
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-03 2014-06-04
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-03 2014-06-04
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-02 2014-06-04
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Common Stock +1,809 $34.05 $61,596 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-06-02 2014-06-04
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-06-02 2014-06-04
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-02 2014-06-04
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-02 2014-06-04
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-02 2014-06-04
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-02 2014-06-04
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-02 2014-06-04
19:27:08
Common Stock +72,980 $34.05 $2,484,969 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-06-02 2014-06-04
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-06-02 2014-06-04
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-02 2014-06-04
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-02 2014-06-04
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-02 2014-06-04
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-02 2014-06-04
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Common Stock +72,980 $34.05 $2,484,969 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-02 2014-06-04
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Common Stock +480 $34.21 $16,421 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-06-02 2014-06-04
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-06-02 2014-06-04
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-02 2014-06-04
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-02 2014-06-04
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-02 2014-06-04
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-02 2014-06-04
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-02 2014-06-04
19:27:08
Common Stock +19,348 $34.21 $661,895 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-06-02 2014-06-04
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2014-06-02 2014-06-04
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-02 2014-06-04
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-02 2014-06-04
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-02 2014-06-04
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-06-02 2014-06-04
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2014-05-16 2014-05-20
20:01:22
Common Stock +3,500 $0.00 $0 A WELCH DANIEL G
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3280 BAYSHORE BOULEVARD

BRISBANE, CA
94005
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  2014-05-16 2014-05-20
19:59:49
Common Stock +3,500 $0.00 $0 A LIPPMAN MARC E
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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  2014-05-16 2014-05-20
19:58:08
Common Stock +3,500 $0.00 $0 A AKKARAJU SRINIVAS
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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  2014-05-16 2014-05-20
19:55:08
Common Stock +3,500 $0.00 $0 A Simonian Nancy A
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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Director EDGAR Filing
  2014-05-16 2014-05-20
19:48:47
Common Stock +3,500 $0.00 $0 A GRYSKA DAVID W
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C/O CELGENE CORPORATION
86 MORRIS AVENUE
SUMMIT, NJ
07901
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  2014-05-14 2014-06-12
20:33:19
Common Stock -325,479 $0.00 $0 G SIEGALL CLAY B
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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  2014-05-09 2014-05-13
20:42:39
Common Stock +10,000 $9.23 $92,300 M HIMES VAUGHN B
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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  2014-04-03 2014-04-07
18:32:01
Common Stock +5,600 $5.92 $33,152 M SIEGALL CLAY B
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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  2014-02-21 2014-02-25
18:04:20
Common Stock +7,500 $12.76 $95,700 M BERGER FRANKLIN M
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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  2014-02-20 2014-02-24
19:25:54
Common Stock -1,241 $53.25 $-66,083 S DRACHMAN JONATHAN G
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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  2014-02-19 2014-02-21
18:39:40
Common Stock -2,088 $52.01 $-108,597 S FULGONI GIAN
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11950 DEMOCRACY DRIVE, 6TH FLOOR

RESTON, VA
20190
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  2014-02-19 2014-02-21
18:39:40
Common Stock -2,088 $52.01 $-108,597 S HIMES VAUGHN B
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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  2014-02-19 2014-02-21
18:39:40
Common Stock +3,000 $9.23 $27,690 M HIMES VAUGHN B
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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EDGAR Filing
  2014-01-21 2014-01-23
20:52:25
Common Stock -14,959 $48.02 $-718,331 S DOBMEIER ERIC
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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EDGAR Filing
  2014-01-21 2014-01-23
20:52:25
Common Stock -19,616 $47.90 $-939,606 S DOBMEIER ERIC
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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EDGAR Filing
  2014-01-21 2014-01-23
20:52:25
Common Stock -21,435 $47.87 $-1,026,093 S DOBMEIER ERIC
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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EDGAR Filing
  2014-01-16 2014-01-21
19:44:44
Common Stock -1,201 $45.75 $-54,946 S DRACHMAN JONATHAN G
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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EDGAR Filing
  2014-01-10 2014-06-12
20:33:19
Common Stock -5,000 $0.00 $0 G SIEGALL CLAY B
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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  2014-01-10 2014-01-14
20:57:17
Common Stock +5,000 $0.00 $0 A Orwin John A
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C/O AFFYMAX, INC.
4001 MIRANDA AVE.
PALO ALTO, CA
94304
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Director EDGAR Filing
  2014-01-02 2014-01-06
18:46:41
Common Stock +1,858 $10.33 $19,193 M SIEGALL CLAY B
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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Director EDGAR Filing
  2013-12-16 2013-12-16
19:42:27
Common Stock +639 $39.91 $25,502 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-16 2013-12-16
19:42:27
Common Stock +639 $39.91 $25,502 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-16 2013-12-16
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Common Stock +639 $39.91 $25,502 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-16 2013-12-16
19:42:27
Common Stock +639 $39.91 $25,502 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-16 2013-12-16
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-16 2013-12-16
19:42:27
Common Stock +639 $39.91 $25,502 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-16 2013-12-16
19:42:27
Common Stock +639 $39.91 $25,502 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-16 2013-12-16
19:42:27
Common Stock +25,596 $39.91 $1,021,536 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-16 2013-12-16
19:42:27
Common Stock +25,596 $39.91 $1,021,536 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-16 2013-12-16
19:42:27
Common Stock +25,596 $39.91 $1,021,536 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-16 2013-12-16
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Common Stock +25,596 $39.91 $1,021,536 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-16 2013-12-16
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-16 2013-12-16
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Common Stock +25,596 $39.91 $1,021,536 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-16 2013-12-16
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Common Stock +25,596 $39.91 $1,021,536 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-16 2013-12-16
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Common Stock +1,280 $39.92 $51,098 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-16 2013-12-16
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-16 2013-12-16
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-16 2013-12-16
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-16 2013-12-16
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-16 2013-12-16
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-16 2013-12-16
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-16 2013-12-16
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Common Stock +51,244 $39.92 $2,045,660 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-16 2013-12-16
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-16 2013-12-16
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-16 2013-12-16
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-16 2013-12-16
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-16 2013-12-16
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-16 2013-12-16
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-13 2013-12-16
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Common Stock +1,063 $39.65 $42,148 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-13 2013-12-16
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-13 2013-12-16
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-13 2013-12-16
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-13 2013-12-16
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-13 2013-12-16
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-13 2013-12-16
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-13 2013-12-16
19:42:27
Common Stock +42,646 $39.65 $1,690,914 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-13 2013-12-16
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-13 2013-12-16
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-13 2013-12-16
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-13 2013-12-16
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-13 2013-12-16
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-13 2013-12-16
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Common Stock +42,646 $39.65 $1,690,914 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-12 2013-12-16
19:42:27
Common Stock +2,486 $39.70 $98,694 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-12 2013-12-16
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-12 2013-12-16
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-12 2013-12-16
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-12 2013-12-16
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-12 2013-12-16
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-12 2013-12-16
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-12 2013-12-16
19:42:27
Common Stock +99,775 $39.70 $3,961,068 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-12 2013-12-16
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-12 2013-12-16
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-12 2013-12-16
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-12 2013-12-16
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
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  2013-12-12 2013-12-16
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-12 2013-12-16
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Common Stock +99,775 $39.70 $3,961,068 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
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  2013-12-12 2013-12-16
19:42:27
Common Stock +1,377 $39.54 $54,447 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-12 2013-12-16
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
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  2013-12-12 2013-12-16
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-12 2013-12-16
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
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  2013-12-12 2013-12-16
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-12 2013-12-16
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-12 2013-12-16
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-12 2013-12-16
19:42:27
Common Stock +55,256 $39.54 $2,184,822 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-12 2013-12-16
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-12 2013-12-16
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-12 2013-12-16
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
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  2013-12-12 2013-12-16
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
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  2013-12-12 2013-12-16
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-12 2013-12-16
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Common Stock +55,256 $39.54 $2,184,822 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-12 2013-12-16
19:42:27
Common Stock +3,056 $39.53 $120,804 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-12 2013-12-16
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
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  2013-12-12 2013-12-16
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-12 2013-12-16
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
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  2013-12-12 2013-12-16
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
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  2013-12-12 2013-12-16
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-12 2013-12-16
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-12 2013-12-16
19:42:27
Common Stock +122,660 $39.53 $4,848,750 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-12 2013-12-16
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-12 2013-12-16
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Common Stock +122,660 $39.53 $4,848,750 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-12 2013-12-16
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Common Stock +122,660 $39.53 $4,848,750 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
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  2013-12-12 2013-12-16
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
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  2013-12-12 2013-12-16
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Common Stock +122,660 $39.53 $4,848,750 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-12 2013-12-16
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Common Stock +122,660 $39.53 $4,848,750 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
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  2013-12-05 2013-12-09
18:38:04
Common Stock +18,996 $5.92 $112,456 M SIEGALL CLAY B
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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  2013-12-05 2013-12-05
20:13:19
Common Stock +5,492 $43.98 $241,538 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-05 2013-12-05
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
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  2013-12-05 2013-12-05
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-05 2013-12-05
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-05 2013-12-05
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
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  2013-12-05 2013-12-05
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
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  2013-12-05 2013-12-05
20:13:19
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
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  2013-12-05 2013-12-05
20:13:19
Common Stock +219,958 $43.98 $9,673,753 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-05 2013-12-05
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-05 2013-12-05
20:13:19
Common Stock +219,958 $43.98 $9,673,753 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-05 2013-12-05
20:13:19
Common Stock +219,958 $43.98 $9,673,753 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-05 2013-12-05
20:13:19
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-05 2013-12-05
20:13:19
Common Stock +219,958 $43.98 $9,673,753 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-05 2013-12-05
20:13:19
Common Stock +219,958 $43.98 $9,673,753 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2013-12-05 2013-12-05
20:13:19
Common Stock +553 $44.00 $24,332 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-05 2013-12-05
20:13:19
Common Stock +553 $44.00 $24,332 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-05 2013-12-05
20:13:19
Common Stock +553 $44.00 $24,332 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-05 2013-12-05
20:13:19
Common Stock +553 $44.00 $24,332 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-05 2013-12-05
20:13:19
Common Stock +553 $44.00 $24,332 P 14159, L.P.
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-05 2013-12-05
20:13:19
Common Stock +553 $44.00 $24,332 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-05 2013-12-05
20:13:19
Common Stock +553 $44.00 $24,332 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2013-12-05 2013-12-05
20:13:19
Common Stock +22,147 $44.00 $974,468 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-05 2013-12-05
20:13:19
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-05 2013-12-05
20:13:19
Common Stock +22,147 $44.00 $974,468 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-05 2013-12-05
20:13:19
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-05 2013-12-05
20:13:19
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-05 2013-12-05
20:13:19
Common Stock +22,147 $44.00 $974,468 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-05 2013-12-05
20:13:19
Common Stock +22,147 $44.00 $974,468 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2013-12-05 2013-12-05
20:13:19
Common Stock +2,863 $44.05 $126,115 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-05 2013-12-05
20:13:19
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-05 2013-12-05
20:13:19
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-05 2013-12-05
20:13:19
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-05 2013-12-05
20:13:19
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-05 2013-12-05
20:13:19
Common Stock +2,863 $44.05 $126,115 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-05 2013-12-05
20:13:19
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2013-12-05 2013-12-05
20:13:19
Common Stock +114,663 $44.05 $5,050,905 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-05 2013-12-05
20:13:19
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-05 2013-12-05
20:13:19
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-05 2013-12-05
20:13:19
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-05 2013-12-05
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-05 2013-12-05
20:13:19
Common Stock +114,663 $44.05 $5,050,905 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-05 2013-12-05
20:13:19
Common Stock +114,663 $44.05 $5,050,905 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2013-12-04 2013-12-05
20:13:19
Common Stock +170 $43.42 $7,381 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-04 2013-12-05
20:13:19
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-04 2013-12-05
20:13:19
Common Stock +170 $43.42 $7,381 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
Common Stock +170 $43.42 $7,381 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
Common Stock +170 $43.42 $7,381 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
Common Stock +170 $43.42 $7,381 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
Common Stock +6,814 $43.42 $295,864 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-04 2013-12-05
20:13:19
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-04 2013-12-05
20:13:19
Common Stock +6,814 $43.42 $295,864 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
Common Stock +6,814 $43.42 $295,864 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
Common Stock +6,814 $43.42 $295,864 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
Common Stock +6,814 $43.42 $295,864 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2013-12-04 2013-12-05
20:13:19
Common Stock +2,512 $42.95 $107,890 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-04 2013-12-05
20:13:19
Common Stock +2,512 $42.95 $107,890 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-04 2013-12-05
20:13:19
Common Stock +2,512 $42.95 $107,890 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
Common Stock +2,512 $42.95 $107,890 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
Common Stock +2,512 $42.95 $107,890 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
Common Stock +100,626 $42.95 $4,321,887 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-04 2013-12-05
20:13:19
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-04 2013-12-05
20:13:19
Common Stock +100,626 $42.95 $4,321,887 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
Common Stock +100,626 $42.95 $4,321,887 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
Common Stock +100,626 $42.95 $4,321,887 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
Common Stock +100,626 $42.95 $4,321,887 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
Common Stock +340 $43.72 $14,865 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-04 2013-12-05
20:13:19
Common Stock +340 $43.72 $14,865 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-04 2013-12-05
20:13:19
Common Stock +340 $43.72 $14,865 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
Common Stock +340 $43.72 $14,865 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
Common Stock +340 $43.72 $14,865 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
Common Stock +340 $43.72 $14,865 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
Common Stock +13,632 $43.72 $595,991 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-04 2013-12-05
20:13:19
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-04 2013-12-05
20:13:19
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
Common Stock +13,632 $43.72 $595,991 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
Common Stock +13,632 $43.72 $595,991 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
Common Stock +1,011 $43.01 $43,483 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-04 2013-12-05
20:13:19
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
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  2013-12-04 2013-12-05
20:13:19
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
Common Stock +40,471 $43.01 $1,740,658 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-04 2013-12-05
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
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  2013-12-04 2013-12-05
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
Common Stock +40,471 $43.01 $1,740,658 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
Common Stock +1,818 $43.20 $78,538 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
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  2013-12-04 2013-12-05
20:13:19
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
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  2013-12-04 2013-12-05
20:13:19
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
Common Stock +1,818 $43.20 $78,538 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
Common Stock +1,818 $43.20 $78,538 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
Common Stock +1,818 $43.20 $78,538 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
Common Stock +72,807 $43.20 $3,145,262 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-04 2013-12-05
20:13:19
Common Stock +72,807 $43.20 $3,145,262 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-04 2013-12-05
20:13:19
Common Stock +72,807 $43.20 $3,145,262 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
Common Stock +72,807 $43.20 $3,145,262 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
Common Stock +72,807 $43.20 $3,145,262 P 14159, L.P.
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
Common Stock +72,807 $43.20 $3,145,262 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2013-12-04 2013-12-05
20:13:19
Common Stock +72,807 $43.20 $3,145,262 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2013-12-04 2013-12-05
20:13:19
Common Stock +455 $43.65 $19,861 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-04 2013-12-05
20:13:19
Common Stock +455 $43.65 $19,861 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-04 2013-12-05
20:13:19
Common Stock +455 $43.65 $19,861 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2013-12-04 2013-12-05
20:13:19
Common Stock +455 $43.65 $19,861 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
Common Stock +455 $43.65 $19,861 P 14159, L.P.
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
Common Stock +455 $43.65 $19,861 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2013-12-04 2013-12-05
20:13:19
Common Stock +455 $43.65 $19,861 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2013-12-04 2013-12-05
20:13:19
Common Stock +18,232 $43.65 $795,827 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-04 2013-12-05
20:13:19
Common Stock +18,232 $43.65 $795,827 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-04 2013-12-05
20:13:19
Common Stock +18,232 $43.65 $795,827 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
Common Stock +18,232 $43.65 $795,827 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
Common Stock +18,232 $43.65 $795,827 P 14159, L.P.
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
Common Stock +18,232 $43.65 $795,827 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
Common Stock +18,232 $43.65 $795,827 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2013-12-04 2013-12-05
20:13:19
Common Stock +290 $42.65 $12,369 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-04 2013-12-05
20:13:19
Common Stock +290 $42.65 $12,369 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-04 2013-12-05
20:13:19
Common Stock +290 $42.65 $12,369 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
Common Stock +290 $42.65 $12,369 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
Common Stock +290 $42.65 $12,369 P 14159, L.P.
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
Common Stock +290 $42.65 $12,369 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
Common Stock +290 $42.65 $12,369 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
Common Stock +11,617 $42.65 $495,465 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-04 2013-12-05
20:13:19
Common Stock +11,617 $42.65 $495,465 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-04 2013-12-05
20:13:19
Common Stock +11,617 $42.65 $495,465 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
Common Stock +11,617 $42.65 $495,465 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
Common Stock +11,617 $42.65 $495,465 P 14159, L.P.
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-04 2013-12-05
20:13:19
Common Stock +11,617 $42.65 $495,465 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2013-12-04 2013-12-05
20:13:19
Common Stock +11,617 $42.65 $495,465 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2013-12-03 2013-12-05
20:13:19
Common Stock +3,551 $42.56 $151,131 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-03 2013-12-05
20:13:19
Common Stock +3,551 $42.56 $151,131 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-03 2013-12-05
20:13:19
Common Stock +3,551 $42.56 $151,131 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2013-12-03 2013-12-05
20:13:19
Common Stock +3,551 $42.56 $151,131 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-03 2013-12-05
20:13:19
Common Stock +3,551 $42.56 $151,131 P 14159, L.P.
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-03 2013-12-05
20:13:19
Common Stock +3,551 $42.56 $151,131 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2013-12-03 2013-12-05
20:13:19
Common Stock +3,551 $42.56 $151,131 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2013-12-03 2013-12-05
20:13:19
Common Stock +142,220 $42.56 $6,052,883 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-03 2013-12-05
20:13:19
Common Stock +142,220 $42.56 $6,052,883 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-03 2013-12-05
20:13:19
Common Stock +142,220 $42.56 $6,052,883 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-03 2013-12-05
20:13:19
Common Stock +142,220 $42.56 $6,052,883 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-03 2013-12-05
20:13:19
Common Stock +142,220 $42.56 $6,052,883 P 14159, L.P.
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-03 2013-12-05
20:13:19
Common Stock +142,220 $42.56 $6,052,883 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-03 2013-12-05
20:13:19
Common Stock +142,220 $42.56 $6,052,883 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2013-12-03 2013-12-05
20:13:19
Common Stock +2,632 $42.41 $111,623 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-03 2013-12-05
20:13:19
Common Stock +2,632 $42.41 $111,623 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-03 2013-12-05
20:13:19
Common Stock +2,632 $42.41 $111,623 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-03 2013-12-05
20:13:19
Common Stock +2,632 $42.41 $111,623 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-03 2013-12-05
20:13:19
Common Stock +2,632 $42.41 $111,623 P 14159, L.P.
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-03 2013-12-05
20:13:19
Common Stock +2,632 $42.41 $111,623 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-03 2013-12-05
20:13:19
Common Stock +2,632 $42.41 $111,623 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2013-12-03 2013-12-05
20:13:19
Common Stock +105,414 $42.41 $4,470,608 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-03 2013-12-05
20:13:19
Common Stock +105,414 $42.41 $4,470,608 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-03 2013-12-05
20:13:19
Common Stock +105,414 $42.41 $4,470,608 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-03 2013-12-05
20:13:19
Common Stock +105,414 $42.41 $4,470,608 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-03 2013-12-05
20:13:19
Common Stock +105,414 $42.41 $4,470,608 P 14159, L.P.
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-03 2013-12-05
20:13:19
Common Stock +105,414 $42.41 $4,470,608 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2013-12-03 2013-12-05
20:13:19
Common Stock +105,414 $42.41 $4,470,608 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2013-12-03 2013-12-05
20:13:19
Common Stock +2,816 $42.31 $119,145 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-03 2013-12-05
20:13:19
Common Stock +2,816 $42.31 $119,145 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-03 2013-12-05
20:13:19
Common Stock +2,816 $42.31 $119,145 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2013-12-03 2013-12-05
20:13:19
Common Stock +2,816 $42.31 $119,145 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-03 2013-12-05
20:13:19
Common Stock +2,816 $42.31 $119,145 P 14159, L.P.
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-03 2013-12-05
20:13:19
Common Stock +2,816 $42.31 $119,145 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2013-12-03 2013-12-05
20:13:19
Common Stock +2,816 $42.31 $119,145 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2013-12-03 2013-12-05
20:13:19
Common Stock +112,797 $42.31 $4,772,441 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-12-03 2013-12-05
20:13:19
Common Stock +112,797 $42.31 $4,772,441 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2013-12-03 2013-12-05
20:13:19
Common Stock +112,797 $42.31 $4,772,441 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-03 2013-12-05
20:13:19
Common Stock +112,797 $42.31 $4,772,441 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-03 2013-12-05
20:13:19
Common Stock +112,797 $42.31 $4,772,441 P 14159, L.P.
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-03 2013-12-05
20:13:19
Common Stock +112,797 $42.31 $4,772,441 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-12-03 2013-12-05
20:13:19
Common Stock +112,797 $42.31 $4,772,441 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2013-11-01 2013-11-05
18:25:08
Common Stock +2,000 $10.33 $20,660 M SIEGALL CLAY B
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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Director EDGAR Filing
  2013-10-31 2013-11-14
19:04:58
Common Stock +8,100 $0.00 $0 A DRACHMAN JONATHAN G
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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EDGAR Filing
  2013-09-10 2013-09-11
19:00:58
Common Stock -2,000 $46.45 $-92,900 S DOBMEIER ERIC
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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EDGAR Filing
  2013-09-10 2013-09-11
19:00:58
Common Stock +15,829 $26.10 $413,137 M DOBMEIER ERIC
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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EDGAR Filing
  2013-09-10 2013-09-11
19:00:58
Common Stock +3,859 $15.46 $59,660 M DOBMEIER ERIC
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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EDGAR Filing
  2013-09-10 2013-09-11
19:00:58
Common Stock +20,312 $20.52 $416,802 M DOBMEIER ERIC
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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EDGAR Filing
  2013-09-05 2013-09-05
19:17:20
Common Stock +15,000 $15.46 $231,900 M DOBMEIER ERIC
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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EDGAR Filing
  2013-09-03 2013-09-05
19:17:20
Common Stock +24,474 $15.46 $378,368 M DOBMEIER ERIC
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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EDGAR Filing
  2013-09-03 2013-09-05
19:17:20
Common Stock +29,193 $12.00 $350,316 M DOBMEIER ERIC
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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EDGAR Filing
  2013-09-03 2013-09-05
19:17:20
Common Stock +6,333 $12.16 $77,009 M DOBMEIER ERIC
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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EDGAR Filing
  2013-09-03 2013-09-05
19:17:20
Common Stock +8,223 $12.16 $99,992 M DOBMEIER ERIC
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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EDGAR Filing
  2013-09-03 2013-09-05
17:55:12
Common Stock -100,000 $43.92 $-4,392,000 S SIEGALL CLAY B
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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Director EDGAR Filing
  2013-09-03 2013-09-05
17:55:12
Common Stock +2,000 $10.33 $20,660 M SIEGALL CLAY B
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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Director EDGAR Filing
  2013-09-03 2013-09-05
17:53:06
Common Stock +10,000 $10.08 $100,800 M GRYSKA DAVID W
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C/O CELGENE CORPORATION
86 MORRIS AVENUE
SUMMIT, NJ
07901
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Director EDGAR Filing
  2013-08-28 2013-08-30
16:30:51
Common Stock +8,223 $12.16 $99,992 M SIMPSON TODD E
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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EDGAR Filing
  2013-08-28 2013-08-30
16:30:51
Common Stock +9,017 $11.09 $99,999 M SIMPSON TODD E
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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EDGAR Filing
  2013-08-28 2013-08-30
16:30:51
Common Stock +13,126 $10.29 $135,067 M SIMPSON TODD E
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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EDGAR Filing
  2013-08-28 2013-08-30
16:30:23
Common Stock +10,000 $12.76 $127,600 M BERGER FRANKLIN M
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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Director EDGAR Filing
  2013-08-27 2013-08-30
16:30:51
Common Stock +12,500 $26.10 $326,250 M SIMPSON TODD E
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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EDGAR Filing
  2013-08-27 2013-08-30
16:30:51
Common Stock +4,166 $15.46 $64,406 M SIMPSON TODD E
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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EDGAR Filing
  2013-08-27 2013-08-30
16:30:51
Common Stock +5,625 $12.00 $67,500 M SIMPSON TODD E
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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EDGAR Filing
  2013-08-27 2013-08-30
16:30:51
Common Stock +2,972 $12.16 $36,140 M SIMPSON TODD E
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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EDGAR Filing
  2013-08-19 2013-08-21
21:37:57
Common Stock +55,000 $0.00 $0 A SIEGALL CLAY B
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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Director EDGAR Filing
  2013-08-19 2013-08-21
21:37:57
Common Stock +55,000 $0.00 $0 A SIMPSON TODD E
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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EDGAR Filing
  2013-08-19 2013-08-21
21:37:57
Common Stock -7,653 $40.91 $-313,084 S SIEGALL CLAY B
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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Director EDGAR Filing
  2013-08-19 2013-08-21
21:29:38
Common Stock +14,400 $0.00 $0 A DOBMEIER ERIC
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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EDGAR Filing
  2013-08-19 2013-08-21
21:29:38
Common Stock +14,400 $0.00 $0 A SIMPSON TODD E
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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EDGAR Filing
  2013-08-19 2013-08-21
21:29:38
Common Stock -3,328 $40.91 $-136,148 S SIMPSON TODD E
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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EDGAR Filing
  2013-08-19 2013-08-21
21:26:19
Common Stock +18,000 $0.00 $0 A DOBMEIER ERIC
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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EDGAR Filing
  2013-08-19 2013-08-21
21:26:19
Common Stock -3,328 $40.91 $-136,148 S DOBMEIER ERIC
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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EDGAR Filing
  2013-08-19 2013-08-21
21:21:52
Common Stock +14,400 $0.00 $0 A HIMES VAUGHN B
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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EDGAR Filing
  2013-08-19 2013-08-21
21:21:52
Common Stock -1,736 $40.91 $-71,020 S HIMES VAUGHN B
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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EDGAR Filing
  2013-08-19 2013-08-21
21:18:18
Common Stock +14,000 $0.00 $0 A BOERNER CHRISTOPHER S.
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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EDGAR Filing
  2013-08-19 2013-08-21
21:18:18
Common Stock -226 $40.91 $-9,246 S BOERNER CHRISTOPHER S.
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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EDGAR Filing
  2013-08-01 2013-08-02
17:49:01
Common Stock +2,000 $10.33 $20,660 M SIEGALL CLAY B
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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Director EDGAR Filing
  2013-07-12 2013-07-15
19:58:41
Common Stock +29,166 $15.46 $450,906 M SIMPSON TODD E
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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EDGAR Filing
  2013-07-12 2013-07-15
19:58:41
Common Stock +18,361 $12.00 $220,332 M SIMPSON TODD E
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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EDGAR Filing
  2013-07-11 2013-07-15
19:58:41
Common Stock +43,514 $12.00 $522,168 M SIMPSON TODD E
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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EDGAR Filing
  2013-07-11 2013-07-15
19:58:41
Common Stock +1,486 $12.16 $18,070 M SIMPSON TODD E
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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EDGAR Filing
  2013-07-01 2013-07-02
16:47:55
Common Stock +2,000 $10.33 $20,660 M SIEGALL CLAY B
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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Director EDGAR Filing
  2013-06-14 2013-06-17
19:28:15
Common Stock +5,000 $8.38 $41,900 M AKKARAJU SRINIVAS
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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Director EDGAR Filing
  2013-06-13 2013-06-17
19:26:42
Common Stock +10,000 $9.23 $92,300 M LICHTENSTEIN WARREN G
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C/O STEEL PARTNERS II, L.P.
590 MADISON AVENUE, 32ND FLOOR
NEW YORK, NY
10022
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Director, Other EDGAR Filing
  2013-06-13 2013-06-17
19:26:42
Common Stock +10,000 $9.23 $92,300 M HIMES VAUGHN B
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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EDGAR Filing
  2013-06-03 2013-06-05
16:48:21
Common Stock +2,000 $10.33 $20,660 M SIEGALL CLAY B
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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Director EDGAR Filing
  2013-06-03 2013-06-05
16:48:21
Common Stock +2,000 $10.33 $20,660 M KRETZMER W BRIAN
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6922 HOLYWOOD BLVD.

LOS ANGELES, CA
90028
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EDGAR Filing
  2013-05-17 2013-05-21
19:38:31
Common Stock +3,500 $0.00 $0 A BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2013-05-17 2013-05-21
19:38:31
Common Stock +3,500 $0.00 $0 A BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2013-05-17 2013-05-21
19:38:31
Common Stock +3,500 $0.00 $0 A BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2013-05-17 2013-05-21
19:38:31
Common Stock +3,500 $0.00 $0 A Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2013-05-17 2013-05-21
19:38:31
Common Stock +3,500 $0.00 $0 A 14159, L.P.
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2013-05-17 2013-05-21
19:38:31
Common Stock +3,500 $0.00 $0 A 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2013-05-17 2013-05-21
18:24:15
Common Stock +3,500 $0.00 $0 A WELCH DANIEL G
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3280 BAYSHORE BOULEVARD

BRISBANE, CA
94005
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Director EDGAR Filing
  2013-05-17 2013-05-21
18:11:56
Common Stock +3,500 $0.00 $0 A Simonian Nancy A
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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Director EDGAR Filing
  2013-05-17 2013-05-21
18:09:58
Common Stock +3,500 $0.00 $0 A MCLAUGHLIN JOHN PETER
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C/O PDL BIOPHARMA, INC.
932 SOUTHWOOD BOULEVARD
INCLINE VILLAGE, NV
89451
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Director EDGAR Filing
  2013-05-17 2013-05-21
18:08:11
Common Stock +3,500 $0.00 $0 A LIPPMAN MARC E
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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Director EDGAR Filing
  2013-05-17 2013-05-21
18:06:50
Common Stock +3,500 $0.00 $0 A BERGER FRANKLIN M
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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Director EDGAR Filing
  2013-05-17 2013-05-21
18:05:58
Common Stock +3,500 $0.00 $0 A GRYSKA DAVID W
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C/O CELGENE CORPORATION
86 MORRIS AVENUE
SUMMIT, NJ
07901
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Director EDGAR Filing
  2013-05-17 2013-05-21
18:01:46
Common Stock +3,500 $0.00 $0 A AKKARAJU SRINIVAS
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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Director EDGAR Filing
  2013-05-10 2013-05-14
09:30:42
Common Stock +17,500 $12.76 $223,300 M AKKARAJU SRINIVAS
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21823 30TH DRIVE SE

BOTHELL, WA
98021
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Director EDGAR Filing
  2013-05-09 2014-05-09
17:16:22
Common Stock +746 $34.60 $25,812 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2013-05-09 2014-05-09
17:16:22
Common Stock +746 $34.60 $25,812 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2013-05-09 2014-05-09
17:16:22
Common Stock +746 $34.60 $25,812 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2013-05-09 2014-05-09
17:16:22
Common Stock +746 $34.60 $25,812 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2013-05-09 2014-05-09
17:16:22
Common Stock +746 $34.60 $25,812 P 14159, L.P.
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2013-05-09 2014-05-09
17:16:22
Common Stock +746 $34.60 $25,812 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2013-05-09 2014-05-09
17:16:22
Common Stock +746 $34.60 $25,812 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2013-05-09 2014-05-09
17:16:22
Common Stock +30,122 $34.60 $1,042,221 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2013-05-09 2014-05-09
17:16:22
Common Stock +30,122 $34.60 $1,042,221 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2013-05-09 2014-05-09
17:16:22
Common Stock +30,122 $34.60 $1,042,221 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2013-05-09 2014-05-09
17:16:22
Common Stock +30,122 $34.60 $1,042,221 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2013-05-09 2014-05-09
17:16:22
Common Stock +30,122 $34.60 $1,042,221 P 14159, L.P.
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2013-05-09 2014-05-09
17:16:22
Common Stock +30,122 $34.60 $1,042,221 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2013-05-09 2014-05-09
17:16:22
Common Stock +30,122 $34.60 $1,042,221 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2013-05-09 2014-05-09
17:16:22
Common Stock +740 $33.73 $24,960 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2013-05-09 2014-05-09
17:16:22
Common Stock +740 $33.73 $24,960 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2013-05-09 2014-05-09
17:16:22
Common Stock +740 $33.73 $24,960 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2013-05-09 2014-05-09
17:16:22
Common Stock +740 $33.73 $24,960 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2013-05-09 2014-05-09
17:16:22
Common Stock +740 $33.73 $24,960 P 14159, L.P.
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2013-05-09 2014-05-09
17:16:22
Common Stock +740 $33.73 $24,960 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2013-05-09 2014-05-09
17:16:22
Common Stock +740 $33.73 $24,960 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2013-05-09 2014-05-09
17:16:22
Common Stock +29,865 $33.73 $1,007,346 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2013-05-09 2014-05-09
17:16:22
Common Stock +29,865 $33.73 $1,007,346 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2013-05-09 2014-05-09
17:16:22
Common Stock +29,865 $33.73 $1,007,346 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2013-05-09 2014-05-09
17:16:22
Common Stock +29,865 $33.73 $1,007,346 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2013-05-09 2014-05-09
17:16:22
Common Stock +29,865 $33.73 $1,007,346 P 14159, L.P.
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2013-05-09 2014-05-09
17:16:22
Common Stock +29,865 $33.73 $1,007,346 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2013-05-09 2014-05-09
17:16:22
Common Stock +29,865 $33.73 $1,007,346 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2013-05-09 2014-05-09
17:16:22
Common Stock +1,069 $34.31 $36,677 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2013-05-09 2014-05-09
17:16:22
Common Stock +1,069 $34.31 $36,677 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2013-05-09 2014-05-09
17:16:22
Common Stock +1,069 $34.31 $36,677 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2013-05-09 2014-05-09
17:16:22
Common Stock +1,069 $34.31 $36,677 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-05-09 2014-05-09
17:16:22
Common Stock +1,069 $34.31 $36,677 P 14159, L.P.
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-05-09 2014-05-09
17:16:22
Common Stock +1,069 $34.31 $36,677 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-05-09 2014-05-09
17:16:22
Common Stock +1,069 $34.31 $36,677 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2013-05-09 2014-05-09
17:16:22
Common Stock +43,131 $34.31 $1,479,825 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2013-05-09 2014-05-09
17:16:22
Common Stock +43,131 $34.31 $1,479,825 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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Director, >=10% Owner EDGAR Filing
  2013-05-09 2014-05-09
17:16:22
Common Stock +43,131 $34.31 $1,479,825 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-05-09 2014-05-09
17:16:22
Common Stock +43,131 $34.31 $1,479,825 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-05-09 2014-05-09
17:16:22
Common Stock +43,131 $34.31 $1,479,825 P 14159, L.P.
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-05-09 2014-05-09
17:16:22
Common Stock +43,131 $34.31 $1,479,825 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2013-05-09 2014-05-09
17:16:22
Common Stock +43,131 $34.31 $1,479,825 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2013-05-09 2014-05-09
17:16:22
Common Stock +783 $33.92 $26,559 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-05-09 2014-05-09
17:16:22
Common Stock +783 $33.92 $26,559 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-05-09 2014-05-09
17:16:22
Common Stock +783 $33.92 $26,559 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2013-05-09 2014-05-09
17:16:22
Common Stock +783 $33.92 $26,559 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-05-09 2014-05-09
17:16:22
Common Stock +783 $33.92 $26,559 P 14159, L.P.
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2013-05-09 2014-05-09
17:16:22
Common Stock +783 $33.92 $26,559 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2013-05-09 2014-05-09
17:16:22
Common Stock +783 $33.92 $26,559 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-05-09 2014-05-09
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Common Stock +31,617 $33.92 $1,072,449 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-05-09 2014-05-09
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-05-09 2014-05-09
17:16:22
Common Stock +31,617 $33.92 $1,072,449 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-05-09 2014-05-09
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Common Stock +31,617 $33.92 $1,072,449 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-05-09 2014-05-09
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-05-09 2014-05-09
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Common Stock +31,617 $33.92 $1,072,449 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-05-09 2014-05-09
17:16:22
Common Stock +31,617 $33.92 $1,072,449 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-05-08 2014-05-09
17:16:22
Common Stock +329 $34.74 $11,429 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-05-08 2014-05-09
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Common Stock +329 $34.74 $11,429 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-05-08 2014-05-09
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Common Stock +329 $34.74 $11,429 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-05-08 2014-05-09
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Common Stock +329 $34.74 $11,429 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-05-08 2014-05-09
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-05-08 2014-05-09
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Common Stock +329 $34.74 $11,429 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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Director, >=10% Owner EDGAR Filing
  2013-05-08 2014-05-09
17:16:22
Common Stock +329 $34.74 $11,429 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-05-08 2014-05-09
17:16:22
Common Stock +13,271 $34.74 $461,035 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-05-08 2014-05-09
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-05-08 2014-05-09
17:16:22
Common Stock +13,271 $34.74 $461,035 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-05-08 2014-05-09
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Common Stock +13,271 $34.74 $461,035 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-05-08 2014-05-09
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-05-08 2014-05-09
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Common Stock +13,271 $34.74 $461,035 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-05-08 2014-05-09
17:16:22
Common Stock +13,271 $34.74 $461,035 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-05-08 2014-05-09
17:16:22
Common Stock +2,933 $33.77 $99,047 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-05-08 2014-05-09
17:16:22
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-05-08 2014-05-09
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-05-08 2014-05-09
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Common Stock +2,933 $33.77 $99,047 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-05-08 2014-05-09
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-05-08 2014-05-09
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Common Stock +2,933 $33.77 $99,047 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-05-08 2014-05-09
17:16:22
Common Stock +2,933 $33.77 $99,047 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-05-08 2014-05-09
17:16:22
Common Stock +118,389 $33.77 $3,997,997 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-05-08 2014-05-09
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-05-08 2014-05-09
17:16:22
Common Stock +118,389 $33.77 $3,997,997 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-05-08 2014-05-09
17:16:22
Common Stock +118,389 $33.77 $3,997,997 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-05-08 2014-05-09
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-05-08 2014-05-09
17:16:22
Common Stock +118,389 $33.77 $3,997,997 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-05-08 2014-05-09
17:16:22
Common Stock +118,389 $33.77 $3,997,997 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-05-08 2014-05-09
17:16:22
Common Stock +839 $33.72 $28,291 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-05-08 2014-05-09
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-05-08 2014-05-09
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Common Stock +839 $33.72 $28,291 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-05-08 2014-05-09
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Common Stock +839 $33.72 $28,291 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-05-08 2014-05-09
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-05-08 2014-05-09
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Common Stock +839 $33.72 $28,291 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-05-08 2014-05-09
17:16:22
Common Stock +839 $33.72 $28,291 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-05-08 2014-05-09
17:16:22
Common Stock +33,868 $34.72 $1,175,897 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-05-08 2014-05-09
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-05-08 2014-05-09
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Common Stock +33,868 $34.72 $1,175,897 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-05-08 2014-05-09
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-05-08 2014-05-09
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-05-08 2014-05-09
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Common Stock +33,868 $34.72 $1,175,897 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-05-08 2014-05-09
17:16:22
Common Stock +33,868 $34.72 $1,175,897 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-05-08 2014-05-09
17:16:22
Common Stock +1,534 $33.98 $52,125 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-05-08 2014-05-09
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-05-08 2014-05-09
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Common Stock +1,534 $33.98 $52,125 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-05-08 2014-05-09
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Common Stock +1,534 $33.98 $52,125 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-05-08 2014-05-09
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-05-08 2014-05-09
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Common Stock +1,534 $33.98 $52,125 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-05-08 2014-05-09
17:16:22
Common Stock +1,534 $33.98 $52,125 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-05-08 2014-05-09
17:16:22
Common Stock +61,892 $33.98 $2,103,090 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-05-08 2014-05-09
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-05-08 2014-05-09
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Common Stock +61,892 $33.98 $2,103,090 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-05-08 2014-05-09
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Common Stock +61,892 $33.98 $2,103,090 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-05-08 2014-05-09
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Common Stock +61,892 $33.98 $2,103,090 P 14159, L.P.
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-05-08 2014-05-09
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Common Stock +61,892 $33.98 $2,103,090 P 667, L.P.
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-05-08 2014-05-09
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Common Stock +61,892 $33.98 $2,103,090 P Baker Bros. Advisors (GP) LLC
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667 MADISION AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-05-07 2014-05-09
17:16:22
Common Stock +623 $34.01 $21,188 P BAKER JULIAN
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-05-07 2014-05-09
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Common Stock +623 $34.01 $21,188 P BAKER FELIX
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667 MADISON AVENUE, 17TH FLOOR

NEW YORK, NY
US 10021
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  2013-05-07 2014-05-09
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Common Stock +623 $34.01 $21,188 P BAKER BROS ADVISORS LLC
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667 MADISON AVENUE 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-05-07 2014-05-09
17:16:22
Common Stock +623 $34.01 $21,188 P Baker Brothers Life Sciences LP
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667 MADISON AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-05-07 2014-05-09
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Common Stock +623 $34.01 $21,188 P 14159, L.P.
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667 MADISION AVENUE, 21ST FLOOR

NEW YORK, NY
US 10065
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  2013-05-07 2014-05-09
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